Protein Domain : IPR000738

Type:  Domain Name:  WHEP-TRS domain
Description:  A conserved domain of 46 amino acids, called WHEP-TRS has been shown []to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to sixtimes in the several enzymes. There are three copies in mammalian multifunctional aminoacyl-tRNA synthetase in a region that separates the N-terminal glutamyl-tRNA synthetase domain from the C-terminal prolyl-tRNA synthetase domain, and six copies in the intercatalytic region of the Drosophila enzyme. The domain is found at the N-terminal extremity of the mammalian tryptophanyl-tRNA synthetase and histidyl-tRNA synthetase, and the mammalian, insect, nematode and plant glycyl-tRNA synthetases []. The structure of a human WHEP-TRS domain has been solved and consists of two helices arranged in a helix-turn-helix []. The WHEP-TRS domain may play a role in the association of tRNA-synthetases into multienzyme complexes []. Short Name:  WHEP-TRS_dom

0 Child Features

0 Contains

4 Cross Referencess


0 Found In

3 GO Annotations

GO Term Gene Name Organism
GO:0004812 IPR000738
GO:0005524 IPR000738
GO:0006418 IPR000738

1 Parent Features

DB identifier Type Name
IPR009068 Domain S15/NS1, RNA-binding

311 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
268427 D8SD08 PAC:15414222 Selaginella moellendorffii 676  
92995 D8RG18 PAC:15422242 Selaginella moellendorffii 563  
418417 D8S5M5 PAC:15406633 Selaginella moellendorffii 531  
evm.model.supercontig_182.1 PAC:16411559 Carica papaya 241  
evm.model.supercontig_78.58 PAC:16426236 Carica papaya 572  
29912.m005417 B9RKD1 PAC:16813294 Ricinus communis 364  
30128.m008560 B9RG03 PAC:16818150 Ricinus communis 686  
Cucsa.178850.1 PAC:16967167 Cucumis sativus 729  
Cucsa.289040.1 A0A0A0LYN5 PAC:16975160 Cucumis sativus 572  
GSVIVT01008654001 D7SH83 PAC:17821225 Vitis vinifera 687  
GSVIVT01036115001 PAC:17841145 Vitis vinifera 262  
orange1.1g040142m PAC:18116065 Citrus sinensis 491  
orange1.1g008405m A0A067EL65 PAC:18104916 Citrus sinensis 567  
orange1.1g010544m A0A067EPW0 PAC:18104917 Citrus sinensis 507  
orange1.1g017368m A0A067EXI6 PAC:18104918 Citrus sinensis 373  
orange1.1g018229m A0A067EY89 PAC:18104919 Citrus sinensis 359  
AT1G70980.1 Q9SSK1 PAC:19653252 Arabidopsis thaliana 571  
AT1G29880.1 O23627 PAC:19649548 Arabidopsis thaliana 729  
AT5G56680.1 Q9SW96 PAC:19672341 Arabidopsis thaliana 572  
Thhalv10000517m V4NJ62 PAC:20208846 Eutrema salsugineum 582  
Thhalv10013096m V4KXL7 PAC:20204939 Eutrema salsugineum 575  
Thhalv10013621m V4LS96 PAC:20204940 Eutrema salsugineum 428  
Thhalv10013626m V4LS96 PAC:20204941 Eutrema salsugineum 428  
Thhalv10006931m V4KV36 PAC:20186954 Eutrema salsugineum 725  
Ciclev10007872m V4UQ58 PAC:20795879 Citrus clementina 567  
Ciclev10004625m V4SAQ7 PAC:20790596 Citrus clementina 578  
Ciclev10004524m V4S5C7 PAC:20790595 Citrus clementina 646  
Carubv10008480m R0IRA8 PAC:20890416 Capsella rubella 690  
Carubv10013104m R0HK00 PAC:20898533 Capsella rubella 691  
Carubv10026156m R0G9A6 PAC:20912553 Capsella rubella 572  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID