Protein Domain : IPR019499

Type:  Domain Name:  Valyl-tRNA synthetase, tRNA-binding arm
Description:  This entry represents the C-terminal domain of Valyl-tRNA synthetase, which consists of two helices in a long alpha-hairpin [].The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, asparticacid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Val-tRNA_synth_tRNA-bd

0 Child Features

0 Contains

2 Cross Referencess


1 Found In

DB identifier Type Name
IPR002303 Family Valine-tRNA ligase

5 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR019499
GO:0004832 IPR019499
GO:0005524 IPR019499
GO:0006438 IPR019499
GO:0005737 IPR019499

1 Parent Features

DB identifier Type Name
IPR010978 Domain tRNA-binding arm

411 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
141956 D8QWX7 PAC:15413568 Selaginella moellendorffii 960  
404784 D8QXC3 PAC:15412607 Selaginella moellendorffii 377  
414168 D8RRV9 PAC:15415177 Selaginella moellendorffii 108  
evm.model.supercontig_116.46 PAC:16406303 Carica papaya 804  
evm.model.supercontig_5.203 PAC:16421311 Carica papaya 299  
28198.m000023 B9T8B4 PAC:16800301 Ricinus communis 518  
27451.m000251 B9SYX0 PAC:16798378 Ricinus communis 247  
Cucsa.031250.1 PAC:16952271 Cucumis sativus 969  
GSVIVT01030775001 D7TSN1 PAC:17837174 Vitis vinifera 653  
GSVIVT01027222001 D7TF60 PAC:17834706 Vitis vinifera 963  
orange1.1g001289m A0A067F684 PAC:18133556 Citrus sinensis 1107  
orange1.1g001303m A0A067F2M2 PAC:18133557 Citrus sinensis 1104  
orange1.1g002136m A0A067EHY8 PAC:18115149 Citrus sinensis 961  
orange1.1g003160m A0A067E6Y7 PAC:18115150 Citrus sinensis 843  
orange1.1g022524m A0A067DL45 PAC:18104050 Citrus sinensis 295  
orange1.1g027314m A0A067DQ63 PAC:18104051 Citrus sinensis 225  
orange1.1g021045m A0A067DKM0 PAC:18129487 Citrus sinensis 318  
AT5G16715.1 F4KE63 PAC:19665624 Arabidopsis thaliana 974  
Thhalv10012577m V4KUN3 PAC:20206495 Eutrema salsugineum 974  
Ciclev10029579m V4RSG5 PAC:20814433 Citrus clementina 126  
Ciclev10022102m V4TUA0 PAC:20806384 Citrus clementina 225  
Ciclev10010998m V4SXS1 PAC:20796240 Citrus clementina 961  
Ciclev10029581m V4RSG5 PAC:20814434 Citrus clementina 126  
Ciclev10004208m V4SEN9 PAC:20790858 Citrus clementina 1107  
Ciclev10029400m V4SAP1 PAC:20814432 Citrus clementina 170  
Ciclev10021431m V4TZG2 PAC:20806383 Citrus clementina 295  
Carubv10011060m R0IE36 PAC:20890086 Capsella rubella 1115  
Carubv10022696m R0FUP9 PAC:20903469 Capsella rubella 759  
Carubv10000149m R0FDH2 PAC:20907339 Capsella rubella 975  
MDP0000579961 PAC:22683472 Malus domestica 391  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID