Protein Domain : IPR002303

Type:  Family Name:  Valine-tRNA ligase
Description:  Valine-tRNA ligase (also known as Valyl-tRNA synthetase) () is an alpha monomer that belongs to class Ia aminoacyl-tRNA ligase.The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Valyl-tRNA_ligase

1 Child Features

DB identifier Type Name
IPR022874 Family Valine-tRNA ligase, type 2

6 Contains

DB identifier Type Name
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR013155 Domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR009008 Domain Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR002300 Domain Aminoacyl-tRNA synthetase, class Ia
IPR019499 Domain Valyl-tRNA synthetase, tRNA-binding arm
IPR001412 Conserved_site Aminoacyl-tRNA synthetase, class I, conserved site

4 Cross Referencess

Identifier
PTHR11946:SF5
PR00986
TIGR00422
MF_02004

0 Found In

4 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR002303
GO:0004832 IPR002303
GO:0005524 IPR002303
GO:0006438 IPR002303

0 Parent Features

699 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
141956 D8QWX7 PAC:15413568 Selaginella moellendorffii 960  
443981 D8S601 PAC:15417664 Selaginella moellendorffii 1031  
evm.model.supercontig_116.46 PAC:16406303 Carica papaya 804  
evm.model.supercontig_2.74 PAC:16412864 Carica papaya 1095  
29777.m000279 B9SWL0 PAC:16808339 Ricinus communis 1065  
27451.m000252 B9SYX1 PAC:16798379 Ricinus communis 694  
Cucsa.166330.1 PAC:16966154 Cucumis sativus 1045  
Cucsa.031250.1 PAC:16952271 Cucumis sativus 969  
GSVIVT01030775001 D7TSN1 PAC:17837174 Vitis vinifera 653  
GSVIVT01030776001 D7TSN2 PAC:17837175 Vitis vinifera 337  
GSVIVT01010632001 PAC:17822742 Vitis vinifera 1106  
GSVIVT01010703001 PAC:17822786 Vitis vinifera 506  
GSVIVT01027222001 D7TF60 PAC:17834706 Vitis vinifera 963  
orange1.1g001289m A0A067F684 PAC:18133556 Citrus sinensis 1107  
orange1.1g001303m A0A067F2M2 PAC:18133557 Citrus sinensis 1104  
orange1.1g001708m A0A067FEK7 PAC:18133558 Citrus sinensis 1022  
orange1.1g001757m A0A067FDX2 PAC:18133559 Citrus sinensis 1017  
orange1.1g002136m A0A067EHY8 PAC:18115149 Citrus sinensis 961  
orange1.1g003160m A0A067E6Y7 PAC:18115150 Citrus sinensis 843  
orange1.1g003586m A0A067E6K5 PAC:18115151 Citrus sinensis 809  
orange1.1g003578m A0A067E6K5 PAC:18115152 Citrus sinensis 809  
orange1.1g005849m A0A067EHZ2 PAC:18115153 Citrus sinensis 674  
orange1.1g007761m A0A067E6Z1 PAC:18115154 Citrus sinensis 590  
AT1G14610.1 P93736 PAC:19649831 Arabidopsis thaliana 1108  
AT5G16715.1 F4KE63 PAC:19665624 Arabidopsis thaliana 974  
Thhalv10012577m V4KUN3 PAC:20206495 Eutrema salsugineum 974  
Thhalv10006628m V4L6G0 PAC:20185556 Eutrema salsugineum 1110  
Thhalv10006653m V4KWE2 PAC:20187368 Eutrema salsugineum 1041  
Ciclev10011095m V4S8L2 PAC:20796242 Citrus clementina 809  
Ciclev10010998m V4SXS1 PAC:20796240 Citrus clementina 961  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971