Protein Domain : IPR016061

Type:  Domain Name:  Proline-tRNA ligase, class II, C-terminal
Description:  Proline tRNA ligase (also known as Prolyl tRNA synthetase) () exists in two forms, which are loosely related. The first form is present in the majority of eubacteria species. The second one, present in some eubacteria, is essentially present in archaea and eukaryota. Proline-tRNA ligase belongs to class IIa. This domain is found at the C-terminal in archaeal and eukaryotic enzymes, as well as in certain bacterial ones.The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Pro-tRNA_ligase_II_C

0 Child Features

0 Contains

3 Cross Referencess


1 Found In

DB identifier Type Name
IPR004499 Family Proline-tRNA ligase, class IIa, archaeal-type

5 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR016061
GO:0004827 IPR016061
GO:0005524 IPR016061
GO:0006433 IPR016061
GO:0005737 IPR016061

1 Parent Features

DB identifier Type Name
IPR017449 Domain Prolyl-tRNA synthetase, class II

531 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
94171 D8RIK0 PAC:15421940 Selaginella moellendorffii 528  
74713 D8QP68 PAC:15412093 Selaginella moellendorffii 495  
evm.model.supercontig_285.2 PAC:16416068 Carica papaya 500  
evm.model.supercontig_54.19 PAC:16422368 Carica papaya 351  
evm.model.supercontig_107.96 PAC:16405405 Carica papaya 544  
30076.m004552 B9RN41 PAC:16817164 Ricinus communis 501  
30169.m006591 B9RIU3 PAC:16821390 Ricinus communis 548  
Cucsa.013990.1 PAC:16951624 Cucumis sativus 468  
Cucsa.049590.1 PAC:16954009 Cucumis sativus 555  
Cucsa.094750.1 A0A0A0KTZ1 PAC:16957781 Cucumis sativus 511  
Cucsa.094750.2 A0A0A0KTZ1 PAC:16957782 Cucumis sativus 511  
GSVIVT01028877001 E0CUX2 PAC:17835876 Vitis vinifera 448  
GSVIVT01020560001 E0CTE7 PAC:17829887 Vitis vinifera 303  
GSVIVT01028250001 D7U2U2 PAC:17835444 Vitis vinifera 516  
orange1.1g010398m A0A067H4L9 PAC:18137303 Citrus sinensis 511  
orange1.1g010413m A0A067H4L9 PAC:18137304 Citrus sinensis 511  
orange1.1g010430m A0A067H4L9 PAC:18137305 Citrus sinensis 511  
orange1.1g019586m A0A067FVC3 PAC:18098776 Citrus sinensis 338  
orange1.1g015587m PAC:18095525 Citrus sinensis 404  
orange1.1g015762m PAC:18095526 Citrus sinensis 401  
orange1.1g047998m A0A067ENV9 PAC:18125422 Citrus sinensis 558  
AT5G52520.1 Q9FYR6 PAC:19667286 Arabidopsis thaliana 543  
AT5G10880.1 Q9LEV2 PAC:19671669 Arabidopsis thaliana 309  
AT3G62120.1 Q9M1R2 PAC:19664205 Arabidopsis thaliana 530  
AT3G62120.2 Q9M1R2 PAC:19664206 Arabidopsis thaliana 530  
AT2G16535.1 A8MR88 PAC:19639056 Arabidopsis thaliana 76  
Thhalv10005900m V4L0R3 PAC:20190206 Eutrema salsugineum 512  
Thhalv10013193m V4LTQ7 PAC:20204648 Eutrema salsugineum 541  
Thhalv10011470m V4JYN4 PAC:20184668 Eutrema salsugineum 451  
Ciclev10031253m V4VAS8 PAC:20803279 Citrus clementina 517  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID