Protein Domain : IPR002314

Type:  Domain Name:  Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.This domain is the core catalytic domain of tRNA synthetases and includes glycyl, prolyl, seryl and threonyl tRNA synthetases. Short Name:  aa-tRNA-synt_IIb

0 Child Features

0 Contains

1 Cross References


11 Found Ins

DB identifier Type Name
IPR006195 Domain Aminoacyl-tRNA synthetase, class II
IPR004499 Family Proline-tRNA ligase, class IIa, archaeal-type
IPR002315 Family Glycyl-tRNA synthetase
IPR002320 Family Threonine-tRNA ligase, class IIa
IPR004516 Family Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
IPR015807 Family Histidine-tRNA ligase
IPR002317 Family Serine-tRNA ligase, type1
IPR004500 Family Prolyl-tRNA synthetase, class IIa, bacterial-type
IPR012739 Family Pyrrolysyl-tRNA ligase
IPR004517 Family ATP phosphoribosyltransferase regulatory subunit
IPR004503 Family Serine-tRNA ligase, class IIa, archaea

4 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR002314
GO:0004812 IPR002314
GO:0005524 IPR002314
GO:0006418 IPR002314

1 Parent Features

DB identifier Type Name
IPR006195 Domain Aminoacyl-tRNA synthetase, class II

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
94171 D8RIK0 PAC:15421940 Selaginella moellendorffii 528  
230438 D8R0P1 PAC:15413946 Selaginella moellendorffii 604  
268427 D8SD08 PAC:15414222 Selaginella moellendorffii 676  
447798 D8T2D3 PAC:15405452 Selaginella moellendorffii 564  
442211 D8RRP1 PAC:15409199 Selaginella moellendorffii 795  
122255 D8SPU2 PAC:15419074 Selaginella moellendorffii 423  
130418 D8T2D2 PAC:15421699 Selaginella moellendorffii 647  
419303 D8S8H4 PAC:15408771 Selaginella moellendorffii 1665  
231245 D8RCX7 PAC:15415292 Selaginella moellendorffii 419  
74713 D8QP68 PAC:15412093 Selaginella moellendorffii 495  
99251 D8RQJ4 PAC:15415093 Selaginella moellendorffii 456  
evm.TU.contig_43454.1 PAC:16431880 Carica papaya 220  
evm.model.supercontig_13.179 PAC:16407690 Carica papaya 439  
evm.model.supercontig_136.10 PAC:16408298 Carica papaya 318  
evm.model.supercontig_258.12 PAC:16415002 Carica papaya 282  
evm.model.supercontig_26.176 PAC:16415112 Carica papaya 450  
evm.model.supercontig_285.2 PAC:16416068 Carica papaya 500  
evm.model.supercontig_36.175 PAC:16418365 Carica papaya 520  
evm.model.supercontig_48.197 PAC:16420836 Carica papaya 386  
evm.model.supercontig_107.96 PAC:16405405 Carica papaya 544  
29608.m000203 B9T183 PAC:16803593 Ricinus communis 658  
29788.m000335 B9SYP6 PAC:16808545 Ricinus communis 119  
29827.m002633 B9S1Q1 PAC:16810064 Ricinus communis 447  
29883.m002043 B9S4M4 PAC:16812130 Ricinus communis 691  
29908.m006072 B9RJP1 PAC:16812893 Ricinus communis 517  
30076.m004552 B9RN41 PAC:16817164 Ricinus communis 501  
30078.m002290 B9S0H3 PAC:16817401 Ricinus communis 503  
30128.m008560 B9RG03 PAC:16818150 Ricinus communis 686  
30162.m001286 B9RKX9 PAC:16820963 Ricinus communis 447  
30169.m006591 B9RIU3 PAC:16821390 Ricinus communis 548  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID