Protein Domain : IPR010097

Type:  Family Name:  Malate dehydrogenase, type 1
Description:  This entry represents the NAD-dependent malate dehydrogenase found in eukaryotes and certain gamma proteobacteria. The enzyme is involved in the citric acid cycle as well as the glyoxalate cycle. Several isoforms exist in eukaryotes. In Saccharomyces cereviseae, for example, there are cytoplasmic, mitochondrial and peroxisomal forms. Although malate dehydrogenases have in some cases been mistaken for lactate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified []which can discriminate between the two activities. Short Name:  Malate_DH_type1

1 Child Features

DB identifier Type Name
IPR023958 Family Malate dehydrogenase, type 1, bacterial

5 Contains

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain
IPR022383 Domain Lactate/malate dehydrogenase, C-terminal
IPR015955 Domain Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR001236 Domain Lactate/malate dehydrogenase, N-terminal
IPR001252 Active_site Malate dehydrogenase, active site

1 Cross References


0 Found In

3 GO Annotations

GO Term Gene Name Organism
GO:0030060 IPR010097
GO:0006108 IPR010097
GO:0055114 IPR010097

1 Parent Features

DB identifier Type Name
IPR001557 Family L-lactate/malate dehydrogenase

784 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
89860 D8RBW3 PAC:15412504 Selaginella moellendorffii 341  
90290 D8RCK2 PAC:15411215 Selaginella moellendorffii 358  
270780 PAC:15422646 Selaginella moellendorffii 352  
133026 D8T6I0 PAC:15405148 Selaginella moellendorffii 351  
evm.model.supercontig_129.41 PAC:16407544 Carica papaya 356  
evm.model.supercontig_131.66 PAC:16408063 Carica papaya 339  
evm.model.supercontig_20.65 PAC:16413092 Carica papaya 329  
evm.model.supercontig_423.5 PAC:16419878 Carica papaya 411  
28830.m000233 B9T172 PAC:16801764 Ricinus communis 332  
29900.m001590 B9S977 PAC:16812468 Ricinus communis 343  
30099.m001624 B9S7S1 PAC:16817645 Ricinus communis 356  
30138.m004069 B9RLY1 PAC:16819434 Ricinus communis 412  
30150.m000471 B9SE47 PAC:16820647 Ricinus communis 345  
Cucsa.197720.1 PAC:16968486 Cucumis sativus 415  
Cucsa.197720.2 PAC:16968487 Cucumis sativus 411  
Cucsa.025280.1 PAC:16952025 Cucumis sativus 412  
Cucsa.103570.1 PAC:16959058 Cucumis sativus 437  
Cucsa.103570.2 PAC:16959059 Cucumis sativus 345  
Cucsa.273480.1 A0A0A0L0E4 PAC:16973831 Cucumis sativus 347  
GSVIVT01021185001 PAC:17830347 Vitis vinifera 296  
GSVIVT01014231001 E0CSB6 PAC:17825259 Vitis vinifera 347  
GSVIVT01036965001 A5BEJ8 PAC:17841735 Vitis vinifera 356  
GSVIVT01006474001 PAC:17819915 Vitis vinifera 356  
orange1.1g023853m A0A067GGE4 PAC:18124727 Citrus sinensis 276  
orange1.1g018265m A0A067GTM8 PAC:18124723 Citrus sinensis 358  
orange1.1g021932m A0A067GJE2 PAC:18124724 Citrus sinensis 305  
orange1.1g022947m A0A067GTN1 PAC:18124725 Citrus sinensis 289  
orange1.1g022997m A0A067GTN1 PAC:18124726 Citrus sinensis 289  
orange1.1g024248m A0A067GGE8 PAC:18124728 Citrus sinensis 270  
orange1.1g026051m A0A067GGN6 PAC:18124729 Citrus sinensis 244  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID