Protein Domain : IPR004364

Type:  Domain Name:  Aminoacyl-tRNA synthetase, class II (D/K/N)
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.This entry includes the asparagine, aspartic acid and lysine tRNA synthetases. Short Name:  aa-tRNA-synt_II

1 Child Features

DB identifier Type Name
IPR018149 Domain Lysyl-tRNA synthetase, class II, C-terminal

1 Contains

DB identifier Type Name
IPR004115 Domain GAD-like domain

1 Cross References


5 Found Ins

DB identifier Type Name
IPR002313 Family Lysine-tRNA ligase, class II
IPR002312 Family Aspartyl/Asparaginyl-tRNA synthetase, class IIb
IPR004523 Family Aspartyl-tRNA synthetase, archaeal-type
IPR004524 Family Aspartate-tRNA ligase, bacterial/mitochondrial-type
IPR004522 Family Asparagine-tRNA ligase

4 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR004364
GO:0004812 IPR004364
GO:0005524 IPR004364
GO:0006418 IPR004364

1 Parent Features

DB identifier Type Name
IPR006195 Domain Aminoacyl-tRNA synthetase, class II

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
79851 D8QXQ7 PAC:15405174 Selaginella moellendorffii 485  
84215 D8R3T7 PAC:15415533 Selaginella moellendorffii 521  
140340 D8QTI9 PAC:15405936 Selaginella moellendorffii 555  
272117 D8T3M2 PAC:15401427 Selaginella moellendorffii 536  
79569 D8QXR0 PAC:15402907 Selaginella moellendorffii 287  
409103 D8RAD5 PAC:15422318 Selaginella moellendorffii 106  
92995 D8RG18 PAC:15422242 Selaginella moellendorffii 563  
418417 D8S5M5 PAC:15406633 Selaginella moellendorffii 531  
114752 D8SDT1 PAC:15421376 Selaginella moellendorffii 294  
428663 D8T3M1 PAC:15415590 Selaginella moellendorffii 480  
evm.TU.contig_43557.1 PAC:16431890 Carica papaya 59  
evm.model.supercontig_119.38 PAC:16406554 Carica papaya 567  
evm.model.supercontig_29.159 PAC:16416187 Carica papaya 375  
evm.model.supercontig_37.195 PAC:16418653 Carica papaya 544  
evm.model.supercontig_78.58 PAC:16426236 Carica papaya 572  
evm.model.supercontig_8.86 PAC:16426683 Carica papaya 632  
evm.model.supercontig_95.40 PAC:16428881 Carica papaya 556  
evm.model.supercontig_1108.1 PAC:16405825 Carica papaya 96  
27744.m000092 B9T475 PAC:16799057 Ricinus communis 58  
27810.m000648 B9SL63 PAC:16799253 Ricinus communis 78  
28708.m000178 B9T485 PAC:16801568 Ricinus communis 657  
28842.m000944 B9SBP3 PAC:16801832 Ricinus communis 585  
29428.m000317 B9SY11 PAC:16802834 Ricinus communis 607  
29910.m000926 B9SBT1 PAC:16813113 Ricinus communis 540  
29912.m005417 B9RKD1 PAC:16813294 Ricinus communis 364  
29916.m000518 B9SSE8 PAC:16813512 Ricinus communis 187  
30099.m001677 B9S7X4 PAC:16817698 Ricinus communis 668  
30099.m001711 B9S808 PAC:16817732 Ricinus communis 206  
30099.m001712 B9S809 PAC:16817733 Ricinus communis 328  
Cucsa.387780.1 A0A0A0K8G1 PAC:16982763 Cucumis sativus 613  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID