Protein Domain : IPR001278

Type:  Family Name:  Arginine-tRNA ligase
Description:  Arginine-tRNA ligase () has been crystallized and preliminary X-ray crystallographic analysis of yeastarginine-tRNA ligase-yeast tRNAArg complexes is available []. The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Arg-tRNA-ligase

0 Child Features

5 Contains

DB identifier Type Name
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR009080 Domain Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR008909 Domain DALR anticodon binding
IPR005148 Domain Arginyl tRNA synthetase N-terminal domain
IPR001412 Conserved_site Aminoacyl-tRNA synthetase, class I, conserved site

5 Cross Referencess

Identifier
PTHR11956
PF00750
TIGR00456
PR01038
MF_00123

0 Found In

3 GO Annotations

GO Term Gene Name Organism
GO:0004814 IPR001278
GO:0005524 IPR001278
GO:0006420 IPR001278

0 Parent Features

438 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
421269 D8SEP7 PAC:15414407 Selaginella moellendorffii 855  
76727 D8QSZ8 PAC:15417941 Selaginella moellendorffii 578  
140217 D8QP34 PAC:15405073 Selaginella moellendorffii 595  
evm.model.supercontig_78.29 PAC:16426204 Carica papaya 231  
evm.model.supercontig_78.27 PAC:16426202 Carica papaya 410  
29679.m000382 B9SYA5 PAC:16805485 Ricinus communis 615  
29912.m005422 B9RKG2 PAC:16813299 Ricinus communis 592  
Cucsa.288730.1 PAC:16975118 Cucumis sativus 645  
Cucsa.288730.2 A0A0A0LYR4 PAC:16975119 Cucumis sativus 590  
Cucsa.288730.3 A0A0A0LYR4 PAC:16975120 Cucumis sativus 590  
GSVIVT01015286001 PAC:17826072 Vitis vinifera 691  
orange1.1g008744m A0A067FTR9 PAC:18116541 Citrus sinensis 555  
orange1.1g010356m A0A067FKE9 PAC:18116543 Citrus sinensis 512  
orange1.1g010043m A0A067FGX3 PAC:18116542 Citrus sinensis 519  
orange1.1g007251m A0A067FGT8 PAC:18116539 Citrus sinensis 611  
orange1.1g008743m A0A067FTR9 PAC:18116540 Citrus sinensis 555  
orange1.1g010832m A0A067FT40 PAC:18116544 Citrus sinensis 499  
orange1.1g014355m A0A067FGU3 PAC:18116545 Citrus sinensis 426  
AT4G26300.1 O23247 PAC:19646553 Arabidopsis thaliana 642  
AT1G66530.1 Q9C713 PAC:19656771 Arabidopsis thaliana 590  
Thhalv10024637m V4P599 PAC:20194988 Eutrema salsugineum 652  
Thhalv10024748m V4LVI4 PAC:20194989 Eutrema salsugineum 590  
Thhalv10024747m V4LVI4 PAC:20194990 Eutrema salsugineum 590  
Thhalv10027313m V4P586 PAC:20193280 Eutrema salsugineum 308  
Thhalv10029198m V4N0T8 PAC:20197854 Eutrema salsugineum 494  
Ciclev10007814m V4TVI3 PAC:20793144 Citrus clementina 589  
Ciclev10007707m V4UJY5 PAC:20793141 Citrus clementina 645  
Ciclev10008013m V4WDI2 PAC:20793148 Citrus clementina 519  
Ciclev10007813m V4TVI3 PAC:20793142 Citrus clementina 589  
Ciclev10007820m V4TVI3 PAC:20793143 Citrus clementina 589  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971
            10739930