Protein Domain : IPR018165

Type:  Domain Name:  Alanyl-tRNA synthetase, class IIc, core domain
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.Alanine-tRNA ligase (also known as alanyl-tRNA synthetase) () is an alpha4 tetramer that belongs to class IIc. Short Name:  Ala-tRNA-synth_IIc_core

0 Child Features

4 Contains

DB identifier Type Name
IPR018163 Domain Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
IPR018164 Domain Alanyl-tRNA synthetase, class IIc, N-terminal
IPR012947 Domain Threonyl/alanyl tRNA synthetase, SAD
IPR018162 Domain Alanine-tRNA ligase, class IIc, anti-codon-binding domain

1 Cross References


2 Found Ins

DB identifier Type Name
IPR002318 Family Alanine-tRNA ligase, class IIc
IPR022429 Family Alanine-tRNA ligase, archaea

4 GO Annotations

GO Term Gene Name Organism
GO:0003676 IPR018165
GO:0004813 IPR018165
GO:0005524 IPR018165
GO:0006419 IPR018165

0 Parent Features

583 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
406072 D8R0K8 PAC:15413099 Selaginella moellendorffii 256  
428079 D8T1N1 PAC:15411020 Selaginella moellendorffii 236  
116848 D8SHA2 PAC:15405711 Selaginella moellendorffii 934  
evm.model.supercontig_1758.1 PAC:16411068 Carica papaya 393  
evm.model.supercontig_20.161 PAC:16412961 Carica papaya 515  
27543.m000154 B9SYR5 PAC:16798660 Ricinus communis 1025  
28349.m000063 B9T776 PAC:16800726 Ricinus communis 815  
Cucsa.192410.1 PAC:16967976 Cucumis sativus 929  
Cucsa.192410.2 PAC:16967977 Cucumis sativus 872  
Cucsa.119340.1 PAC:16960972 Cucumis sativus 999  
GSVIVT01024313001 D7T7I5 PAC:17832546 Vitis vinifera 267  
GSVIVT01024320001 D7T7J0 PAC:17832551 Vitis vinifera 960  
GSVIVT01012030001 PAC:17823758 Vitis vinifera 1026  
GSVIVT01023918001 D7U4W0 PAC:17832227 Vitis vinifera 1006  
GSVIVT01017755001 PAC:17827875 Vitis vinifera 243  
orange1.1g025098m PAC:18109831 Citrus sinensis 258  
orange1.1g002252m A0A067FQ29 PAC:18099342 Citrus sinensis 947  
orange1.1g002994m A0A067FYH0 PAC:18099343 Citrus sinensis 860  
orange1.1g004366m A0A067FXS4 PAC:18099344 Citrus sinensis 759  
orange1.1g004997m A0A067FLL5 PAC:18099345 Citrus sinensis 720  
orange1.1g002583m A0A067ED20 PAC:18115870 Citrus sinensis 904  
orange1.1g003915m A0A067EP45 PAC:18115872 Citrus sinensis 787  
orange1.1g001826m A0A067ED15 PAC:18115864 Citrus sinensis 1009  
orange1.1g001871m A0A067EGD8 PAC:18115865 Citrus sinensis 1002  
orange1.1g001932m A0A067EP40 PAC:18115866 Citrus sinensis 995  
orange1.1g002074m A0A067EPX5 PAC:18115867 Citrus sinensis 972  
orange1.1g002171m A0A067ECQ3 PAC:18115868 Citrus sinensis 957  
orange1.1g002324m A0A067EGE2 PAC:18115869 Citrus sinensis 936  
orange1.1g003144m A0A067EPY0 PAC:18115871 Citrus sinensis 844  
AT1G50200.1 P36428 PAC:19658099 Arabidopsis thaliana 1003  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID