Protein Domain : IPR015866

Type:  Domain Name:  Serine-tRNA synthetase, type1, N-terminal
Description:  This entry represents the N-terminal domain of Serine-tRNA synthetase, which consists of two helices in a long alpha-hairpin. Serine-tRNA synthetase () exists as monomer and belongs to class IIa aminoacyl-tRNA synthetase [].The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Ser-tRNA-synth_1_N

0 Child Features

0 Contains

2 Cross Referencess


1 Found In

DB identifier Type Name
IPR002317 Family Serine-tRNA ligase, type1

0 GO Annotation

1 Parent Features

DB identifier Type Name
IPR010978 Domain tRNA-binding arm

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
405518 D8QYU5 PAC:15413928 Selaginella moellendorffii 279  
140333 D8QTI5 PAC:15405905 Selaginella moellendorffii 506  
75677 D8QPM1 PAC:15414473 Selaginella moellendorffii 276  
231245 D8RCX7 PAC:15415292 Selaginella moellendorffii 419  
75154 D8QPD2 PAC:15410559 Selaginella moellendorffii 238  
99251 D8RQJ4 PAC:15415093 Selaginella moellendorffii 456  
evm.TU.contig_40463.1 PAC:16431484 Carica papaya 81  
evm.model.supercontig_26.176 PAC:16415112 Carica papaya 450  
evm.model.supercontig_34.108 PAC:16417836 Carica papaya 366  
evm.model.supercontig_36.175 PAC:16418365 Carica papaya 520  
evm.model.supercontig_36.180 PAC:16418371 Carica papaya 268  
evm.model.supercontig_47.78 PAC:16420685 Carica papaya 161  
evm.model.supercontig_48.197 PAC:16420836 Carica papaya 386  
evm.model.supercontig_8.156 PAC:16426437 Carica papaya 605  
29607.m000239 B9SZ25 PAC:16803586 Ricinus communis 315  
29739.m003617 B9RQW6 PAC:16807397 Ricinus communis 280  
29788.m000334 B9SYP5 PAC:16808544 Ricinus communis 355  
29827.m002631 B9S1P9 PAC:16810062 Ricinus communis 250  
29827.m002633 B9S1Q1 PAC:16810064 Ricinus communis 447  
29908.m006072 B9RJP1 PAC:16812893 Ricinus communis 517  
29908.m006074 B9RJP3 PAC:16812895 Ricinus communis 388  
29908.m006078 B9RJP7 PAC:16812899 Ricinus communis 380  
30147.m014222 B9R9S8 PAC:16820234 Ricinus communis 832  
30162.m001286 B9RKX9 PAC:16820963 Ricinus communis 447  
38088.m000015 B9TME6 PAC:16827093 Ricinus communis 317  
30174.m009079 B9REB2 PAC:16822720 Ricinus communis 180  
30202.m000258 B9SU55 PAC:16823839 Ricinus communis 128  
30204.m001763 B9S529 PAC:16823881 Ricinus communis 610  
Cucsa.352220.1 A0A0A0KZS2 PAC:16979975 Cucumis sativus 815  
Cucsa.152690.2 PAC:16964575 Cucumis sativus 138  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID