Protein Domain : IPR001557

Type:  Family Name:  L-lactate/malate dehydrogenase
Description:  This family contains both lactate and malate dehydrogenases. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle.L-lactate dehydrogenase () (LDH) []catalyses the reversible NAD-dependent interconversion of pyruvate to L-lactate. In vertebrate muscles and in lactic acid bacteria it represents the final step in anaerobic glycolysis. This tetrameric enzyme is present in prokaryotic and eukaryotic organisms. In vertebrates there are three isozymes of LDH: the M form (LDH-A), found predominantly in muscle tissues; the H form (LDH-B), found in heart muscle and the X form (LDH-C), found only in the spermatozoa of mammals and birds. In birds and crocodilian eye lenses, LDH-B serves as a structural protein and is known as epsilon-crystallin [].L-2-hydroxyisocaproate dehydrogenase () (L-hicDH) []catalyses the reversible and stereospecific interconversion between 2-ketocarboxylic acids and L-2-hydroxy-carboxylic acids. L-hicDH is evolutionary related to LDH's. Short Name:  L-lactate/malate_DH

4 Child Features

DB identifier Type Name
IPR010945 Family Malate dehydrogenase, type 2
IPR010097 Family Malate dehydrogenase, type 1
IPR011304 Family L-lactate dehydrogenase
IPR011275 Family Malate dehydrogenase, type 3

5 Contains

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain
IPR022383 Domain Lactate/malate dehydrogenase, C-terminal
IPR015955 Domain Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR001236 Domain Lactate/malate dehydrogenase, N-terminal
IPR018177 Active_site L-lactate dehydrogenase, active site

3 Cross Referencess


0 Found In

3 GO Annotations

GO Term Gene Name Organism
GO:0016616 IPR001557
GO:0019752 IPR001557
GO:0055114 IPR001557

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
271992 D8SY75 PAC:15404726 Selaginella moellendorffii 331  
89860 D8RBW3 PAC:15412504 Selaginella moellendorffii 341  
90290 D8RCK2 PAC:15411215 Selaginella moellendorffii 358  
270780 PAC:15422646 Selaginella moellendorffii 352  
405919 D8R035 PAC:15416888 Selaginella moellendorffii 300  
92401 D8RFP2 PAC:15418338 Selaginella moellendorffii 340  
133026 D8T6I0 PAC:15405148 Selaginella moellendorffii 351  
evm.model.supercontig_129.41 PAC:16407544 Carica papaya 356  
evm.model.supercontig_131.66 PAC:16408063 Carica papaya 339  
evm.model.supercontig_20.65 PAC:16413092 Carica papaya 329  
evm.model.supercontig_29.108 PAC:16416131 Carica papaya 350  
evm.model.supercontig_423.5 PAC:16419878 Carica papaya 411  
evm.model.supercontig_44.59 PAC:16420199 Carica papaya 354  
28830.m000233 B9T172 PAC:16801764 Ricinus communis 332  
29200.m000165 B9T5E4 PAC:16802447 Ricinus communis 332  
29636.m000768 B9SIT3 PAC:16804368 Ricinus communis 350  
29636.m000769 B9SIT4 PAC:16804369 Ricinus communis 350  
29900.m001590 B9S977 PAC:16812468 Ricinus communis 343  
30099.m001624 B9S7S1 PAC:16817645 Ricinus communis 356  
30138.m004069 B9RLY1 PAC:16819434 Ricinus communis 412  
30150.m000471 B9SE47 PAC:16820647 Ricinus communis 345  
30174.m008801 B9RD45 PAC:16822446 Ricinus communis 332  
Cucsa.383610.1 A0A0A0LII5 PAC:16982415 Cucumis sativus 333  
Cucsa.383610.4 A0A0A0LII5 PAC:16982418 Cucumis sativus 333  
Cucsa.383610.5 PAC:16982419 Cucumis sativus 327  
Cucsa.197720.1 PAC:16968486 Cucumis sativus 415  
Cucsa.197720.2 PAC:16968487 Cucumis sativus 411  
Cucsa.301890.1 PAC:16975678 Cucumis sativus 350  
Cucsa.301900.1 PAC:16975679 Cucumis sativus 350  
Cucsa.025280.1 PAC:16952025 Cucumis sativus 412  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID