Protein Domain : IPR015955

Type:  Domain Name:  Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Description:  This entry represents a structural motif found at the C-terminal of lactate dehydrogenase ()and malate dehydrogenases (), as well as at the C-terminal of family 4 glycoside hydrolases (). These domains have an unusual fold consisting of segregated alpha-helical and beta-sheet regions, although they contain predominantly anti-parallel beta-sheets [, , ].L-lactate dehydrogenases are metabolic enzymes that catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle.O-Glycosyl hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Glycoside hydrolase family 4 comprises enzymes with several known activities; 6-phospho-beta-glucosidase (); 6-phospho-alpha-glucosidase (); alpha-galactosidase (). Short Name:  Lactate_DH/Glyco_Ohase_4_C

2 Child Features

DB identifier Type Name
IPR022383 Domain Lactate/malate dehydrogenase, C-terminal
IPR022616 Domain Glycosyl hydrolase, family 4, C-terminal

2 Contains

DB identifier Type Name
IPR001252 Active_site Malate dehydrogenase, active site
IPR018177 Active_site L-lactate dehydrogenase, active site

2 Cross Referencess

Identifier
G3DSA:3.90.110.10
SSF56327

9 Found Ins

DB identifier Type Name
IPR001557 Family L-lactate/malate dehydrogenase
IPR010945 Family Malate dehydrogenase, type 2
IPR011274 Family Malate dehydrogenase, NAD-dependent, cytosolic
IPR010097 Family Malate dehydrogenase, type 1
IPR011273 Family Malate dehydrogenase, NADP-dependent, plants
IPR011304 Family L-lactate dehydrogenase
IPR001088 Family Glycoside hydrolase, family 4
IPR011272 Family Lactate dehydrogenase, protist
IPR011275 Family Malate dehydrogenase, type 3

4 GO Annotations

GO Term Gene Name Organism
GO:0003824 IPR015955
GO:0016616 IPR015955
GO:0005975 IPR015955
GO:0055114 IPR015955

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
271992 D8SY75 PAC:15404726 Selaginella moellendorffii 331  
431542 D8TD03 PAC:15401408 Selaginella moellendorffii 826  
89860 D8RBW3 PAC:15412504 Selaginella moellendorffii 341  
90290 D8RCK2 PAC:15411215 Selaginella moellendorffii 358  
270710 D8RBD7 PAC:15422450 Selaginella moellendorffii 447  
270780 PAC:15422646 Selaginella moellendorffii 352  
405919 D8R035 PAC:15416888 Selaginella moellendorffii 300  
407586 D8R631 PAC:15419819 Selaginella moellendorffii 168  
92401 D8RFP2 PAC:15418338 Selaginella moellendorffii 340  
421109 D8SE66 PAC:15413480 Selaginella moellendorffii 217  
430321 D8T913 PAC:15419263 Selaginella moellendorffii 677  
133026 D8T6I0 PAC:15405148 Selaginella moellendorffii 351  
evm.TU.contig_42550.1 PAC:16431761 Carica papaya 73  
evm.TU.contig_28082.2 PAC:16429545 Carica papaya 324  
evm.TU.contig_33425.1 PAC:16430269 Carica papaya 93  
evm.model.supercontig_116.21 PAC:16406276 Carica papaya 221  
evm.model.supercontig_129.41 PAC:16407544 Carica papaya 356  
evm.model.supercontig_130.32 PAC:16407936 Carica papaya 112  
evm.model.supercontig_131.66 PAC:16408063 Carica papaya 339  
evm.model.supercontig_20.65 PAC:16413092 Carica papaya 329  
evm.model.supercontig_209.22 PAC:16413337 Carica papaya 103  
evm.model.supercontig_29.108 PAC:16416131 Carica papaya 350  
evm.model.supercontig_29.115 PAC:16416139 Carica papaya 484  
evm.model.supercontig_47.35 PAC:16420638 Carica papaya 60  
evm.model.supercontig_423.5 PAC:16419878 Carica papaya 411  
evm.model.supercontig_44.59 PAC:16420199 Carica papaya 354  
evm.model.supercontig_706.3 PAC:16425408 Carica papaya 339  
27999.m000061 B9T7Q0 PAC:16799751 Ricinus communis 409  
28161.m000232 B9T3M4 PAC:16800116 Ricinus communis 74  
28830.m000233 B9T172 PAC:16801764 Ricinus communis 332  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7624375
            8535779
            11276087
            8117664
            12588867