Protein Domain : IPR013761

Type:  Domain Name:  Sterile alpha motif/pointed domain
Description:  Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway []. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA []. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases []; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies []; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord []; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp []; p73, a p53 homologue involved in neuronal development []; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes []. Short Name:  SAM/pointed

3 Child Features

DB identifier Type Name
IPR001660 Domain Sterile alpha motif domain
IPR015316 Domain Ste50, sterile alpha motif
IPR003118 Domain Pointed domain

0 Contains

2 Cross Referencess


3 Found Ins

DB identifier Type Name
IPR020766 Family Receptor-like tyrosine-protein kinase kin-15/kin-16
IPR016257 Family Ephrin receptor type-A /type-B
IPR017239 Family Mitogen-activated protein (MAP) kinase kinase kinase Ste11, Cryptococcus

0 GO Annotation

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
228154 D8RP06 PAC:15405349 Selaginella moellendorffii 125  
403355 D8QTX0 PAC:15406460 Selaginella moellendorffii 416  
410658 D8RFF9 PAC:15407123 Selaginella moellendorffii 266  
414539 D8RT36 PAC:15418120 Selaginella moellendorffii 267  
430485 D8T9K2 PAC:15420172 Selaginella moellendorffii 130  
440917 D8RFE1 PAC:15408661 Selaginella moellendorffii 496  
270990 D8RNS3 PAC:15401922 Selaginella moellendorffii 255  
402871 D8QNB3 PAC:15407344 Selaginella moellendorffii 859  
61072 D8RD87 PAC:15413287 Selaginella moellendorffii 771  
415023 D8RUD1 PAC:15417198 Selaginella moellendorffii 679  
415475 D8RW82 PAC:15420377 Selaginella moellendorffii 769  
420919 D8SDJ3 PAC:15416625 Selaginella moellendorffii 656  
424623 D8SQI4 PAC:15403650 Selaginella moellendorffii 327  
81847 D8R0Q2 PAC:15411397 Selaginella moellendorffii 244  
414540 D8RT37 PAC:15418138 Selaginella moellendorffii 130  
evm.model.supercontig_3.228 PAC:16416511 Carica papaya 307  
evm.TU.contig_46948.1 PAC:16432357 Carica papaya 78  
evm.model.supercontig_10.135 PAC:16404488 Carica papaya 198  
evm.model.supercontig_100.17 PAC:16404728 Carica papaya 79  
evm.model.supercontig_1212.2 PAC:16407044 Carica papaya 202  
evm.model.supercontig_1218.3 PAC:16407054 Carica papaya 231  
evm.model.supercontig_135.3 PAC:16408268 Carica papaya 162  
evm.model.supercontig_14.83 PAC:16408834 Carica papaya 258  
evm.model.supercontig_1483.1 PAC:16409282 Carica papaya 591  
evm.model.supercontig_159.26 PAC:16409917 Carica papaya 96  
evm.model.supercontig_1750.2 PAC:16411065 Carica papaya 190  
evm.model.supercontig_2198.1 PAC:16413843 Carica papaya 225  
evm.model.supercontig_222.4 PAC:16413996 Carica papaya 263  
evm.model.supercontig_25.141 PAC:16414736 Carica papaya 270  
evm.model.supercontig_265.1 PAC:16415430 Carica papaya 244  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID