Protein Domain : IPR000403

Type:  Domain Name:  Phosphatidylinositol 3-/4-kinase, catalytic domain
Description:  Phosphatidylinositol 3-kinase (PI3-kinase) () []is an enzymethat phosphorylates phosphoinositides on the 3-hydroxyl group of the inositolring. The three products of PI3-kinase - PI-3-P,PI-3,4-P(2) and PI-3,4,5-P(3) function as secondary messengers in cell signalling.Phosphatidylinositol 4-kinase (PI4-kinase) () []is an enzymethat acts on phosphatidylinositol (PI) in thefirst committed step in theproduction of the secondary messenger inositol-1'4'5'-trisphosphate. This domain is also present in a wide range of protein kinases, involved in diverse cellular functions, such as control of cell growth, regulation of cell cycle progression, a DNA damage checkpoint, recombination, and maintenance of telomere length. Despite significant homology to lipid kinases, no lipid kinase activity has been demonstrated for any of the PIK-related kinases [].The PI3- and PI4-kinases share a well conserved domain at their C-terminalsection; this domain seems to be distantly related to the catalytic domain ofprotein kinases [, ]. The catalytic domain of PI3K has the typical bilobal structure that is seen in other ATP-dependentkinases, with a small N-terminal lobe and a large C-terminal lobe. The core of this domain is the most conserved region of the PI3Ks.The ATP cofactor binds in the crevice formed by the N-and C-terminal lobes, a loop between two strands providesa hydrophobic pocket for binding of the adenine moiety, and a lysine residue interactswith the alpha-phosphate. In contrast to protein kinases, the PI3K loop which interacts with thephosphates of the ATP and is known as the glycine-rich or P-loop, contains no glycine residues.Instead, contact with the ATP -phosphate is maintained through the side chain of a conserved serineresidue. Short Name:  PI3/4_kinase_cat_dom

0 Child Features

1 Contains

DB identifier Type Name
IPR018936 Conserved_site Phosphatidylinositol 3/4-kinase, conserved site

4 Cross Referencess

Identifier
PS50290
PF00454
SM00146
G3DSA:1.10.1070.11

4 Found Ins

DB identifier Type Name
IPR015433 Family Phosphatidylinositol Kinase
IPR008290 Family Phosphatidylinositol 3-kinase, Vps34 type
IPR015519 Family ATM
IPR022292 Family Conserved hypothetical protein CHP03843

1 GO Annotation

GO Term Gene Name Organism
GO:0016773 IPR000403

1 Parent Features

DB identifier Type Name
IPR011009 Domain Protein kinase-like domain

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
21497 D8QXQ6 PAC:15409874 Selaginella moellendorffii 570  
88215 D8R9U2 PAC:15404717 Selaginella moellendorffii 2922  
97360 D8RMQ9 PAC:15410005 Selaginella moellendorffii 803  
109582 D8S5T6 PAC:15405049 Selaginella moellendorffii 457  
118849 D8SKG0 PAC:15411645 Selaginella moellendorffii 790  
231673 D8RI64 PAC:15418384 Selaginella moellendorffii 563  
91734 D8REM7 PAC:15417760 Selaginella moellendorffii 601  
84321 D8R478 PAC:15416269 Selaginella moellendorffii 524  
98463 D8RPG5 PAC:15413762 Selaginella moellendorffii 3780  
413509 D8RPQ3 PAC:15415169 Selaginella moellendorffii 2298  
149153 D8RRA8 PAC:15408403 Selaginella moellendorffii 520  
42373 D8SNR2 PAC:15403917 Selaginella moellendorffii 436  
125024 D8SU58 PAC:15403751 Selaginella moellendorffii 732  
110199 D8S7B4 PAC:15405243 Selaginella moellendorffii 1936  
269945 D8TAD9 PAC:15420906 Selaginella moellendorffii 957  
92319 D8RG87 PAC:15417597 Selaginella moellendorffii 1744  
97324 D8RMV0 PAC:15409901 Selaginella moellendorffii 1072  
evm.model.supercontig_3.223 PAC:16416506 Carica papaya 393  
evm.model.supercontig_3.81 PAC:16416868 Carica papaya 367  
evm.model.supercontig_3.78 PAC:16416864 Carica papaya 186  
evm.model.supercontig_1.172 PAC:16404091 Carica papaya 490  
evm.model.supercontig_20.125 PAC:16412921 Carica papaya 2015  
evm.model.supercontig_14.244 PAC:16408752 Carica papaya 613  
evm.model.supercontig_42.143 PAC:16419727 Carica papaya 1102  
evm.model.supercontig_520.2 PAC:16422129 Carica papaya 848  
evm.model.supercontig_6.250 PAC:16423432 Carica papaya 825  
evm.model.supercontig_62.125 PAC:16423923 Carica papaya 1151  
evm.model.supercontig_69.63 PAC:16424935 Carica papaya 814  
evm.model.supercontig_76.54 PAC:16426024 Carica papaya 905  
evm.model.supercontig_79.17 PAC:16426299 Carica papaya 582  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1322797
            8387896
            8194527
            12151228
            12456783