Protein Domain : IPR007638

Type:  Domain Name:  Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.This is a region found N-terminal to the catalytic domain of glutaminyl-tRNA synthetase () in eukaryotes but not in Escherichia coli. This region is thought to bind RNA in a non-specific manner, enhancing interactions between the tRNA and enzyme, but is not essential for enzyme function []. Short Name:  Gln-tRNA-synth_Ib_RNA-bd_2

0 Child Features

0 Contains

1 Cross References

Identifier
PF04557

0 Found In

5 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR007638
GO:0004819 IPR007638
GO:0005524 IPR007638
GO:0006425 IPR007638
GO:0005737 IPR007638

0 Parent Features

199 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
168502 D8R589 PAC:15422789 Selaginella moellendorffii 767  
evm.model.supercontig_798.2 PAC:16426373 Carica papaya 795  
30066.m000715 B9SLX3 PAC:16816481 Ricinus communis 793  
Cucsa.109570.1 A0A0A0LIR0 PAC:16959890 Cucumis sativus 794  
Cucsa.234080.1 A0A0A0LMF7 PAC:16970337 Cucumis sativus 793  
GSVIVT01018308001 D7SM09 PAC:17828299 Vitis vinifera 790  
GSVIVT01011871001 D7T929 PAC:17823632 Vitis vinifera 791  
orange1.1g006869m A0A067GNF2 PAC:18139053 Citrus sinensis 628  
orange1.1g003751m A0A067GBB7 PAC:18139049 Citrus sinensis 798  
orange1.1g003764m A0A067GBI4 PAC:18139050 Citrus sinensis 797  
orange1.1g004119m A0A067GE73 PAC:18139051 Citrus sinensis 773  
orange1.1g004546m A0A067GNR0 PAC:18139052 Citrus sinensis 745  
orange1.1g007060m A0A067GBC2 PAC:18139054 Citrus sinensis 619  
AT1G25350.2 F4ICG2 PAC:19655198 Arabidopsis thaliana 800  
AT1G25350.1 Q8W4F3 PAC:19655199 Arabidopsis thaliana 795  
Thhalv10006840m V4KSE7 PAC:20187784 Eutrema salsugineum 795  
Ciclev10014367m V4W6G7 PAC:20818597 Citrus clementina 762  
Ciclev10014320m V4UHD9 PAC:20818595 Citrus clementina 797  
Ciclev10014321m V4U700 PAC:20818596 Citrus clementina 796  
Ciclev10014443m V4TMK2 PAC:20818598 Citrus clementina 710  
Carubv10008339m R0GM02 PAC:20893253 Capsella rubella 795  
Carubv10022284m R0HXX8 PAC:20905447 Capsella rubella 762  
Carubv10015599m R0I7A4 PAC:20897616 Capsella rubella 734  
MDP0000320645 PAC:22659573 Malus domestica 1254  
MDP0000304937 PAC:22676772 Malus domestica 1178  
Lus10041433 PAC:23146663 Linum usitatissimum 793  
Lus10034339 PAC:23176092 Linum usitatissimum 1091  
Potri.008G122200.3 PAC:27036142 Populus trichocarpa 791  
Potri.008G122200.1 PAC:27036140 Populus trichocarpa 792  
Potri.008G122200.4 B9HJ44 PAC:27036143 Populus trichocarpa 786  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971
            10347214