Protein Domain : IPR006195

Type:  Domain Name:  Aminoacyl-tRNA synthetase, class II
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.This entry recognises all class-II enzymes except for heterodimeric glycyl-tRNA synthetases and alanyl-tRNA synthetases. Short Name:  aa-tRNA-synth_II

2 Child Features

DB identifier Type Name
IPR004364 Domain Aminoacyl-tRNA synthetase, class II (D/K/N)
IPR002314 Domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)

3 Contains

DB identifier Type Name
IPR002314 Domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
IPR004115 Domain GAD-like domain
IPR007214 Domain YbaK/aminoacyl-tRNA synthetase-associated domain

1 Cross References


20 Found Ins

DB identifier Type Name
IPR002319 Domain Phenylalanyl-tRNA synthetase
IPR018150 Family Aminoacyl-tRNA synthetase, class II (D/K/N)-like
IPR002313 Family Lysine-tRNA ligase, class II
IPR002312 Family Aspartyl/Asparaginyl-tRNA synthetase, class IIb
IPR004523 Family Aspartyl-tRNA synthetase, archaeal-type
IPR004499 Family Proline-tRNA ligase, class IIa, archaeal-type
IPR004524 Family Aspartate-tRNA ligase, bacterial/mitochondrial-type
IPR002315 Family Glycyl-tRNA synthetase
IPR004529 Family Phenylalanyl-tRNA synthetase, class IIc, alpha subunit
IPR002320 Family Threonine-tRNA ligase, class IIa
IPR004522 Family Asparagine-tRNA ligase
IPR004516 Family Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
IPR015807 Family Histidine-tRNA ligase
IPR002317 Family Serine-tRNA ligase, type1
IPR004530 Family Phenylalanyl-tRNA synthetase, class IIc, mitochondrial
IPR004500 Family Prolyl-tRNA synthetase, class IIa, bacterial-type
IPR005246 Family O-phosphoseryl-tRNA(Cys) ligase
IPR012739 Family Pyrrolysyl-tRNA ligase
IPR004618 Family Aspartate--ammonia ligase
IPR004517 Family ATP phosphoribosyltransferase regulatory subunit

2 GO Annotations

GO Term Gene Name Organism
GO:0004812 IPR006195
GO:0006418 IPR006195

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
165421 PAC:15413457 Selaginella moellendorffii 470  
79851 D8QXQ7 PAC:15405174 Selaginella moellendorffii 485  
84215 D8R3T7 PAC:15415533 Selaginella moellendorffii 521  
94171 D8RIK0 PAC:15421940 Selaginella moellendorffii 528  
140340 D8QTI9 PAC:15405936 Selaginella moellendorffii 555  
230438 D8R0P1 PAC:15413946 Selaginella moellendorffii 604  
231153 D8RBE9 PAC:15414604 Selaginella moellendorffii 499  
268427 D8SD08 PAC:15414222 Selaginella moellendorffii 676  
272117 D8T3M2 PAC:15401427 Selaginella moellendorffii 536  
447798 D8T2D3 PAC:15405452 Selaginella moellendorffii 564  
79569 D8QXR0 PAC:15402907 Selaginella moellendorffii 287  
442211 D8RRP1 PAC:15409199 Selaginella moellendorffii 795  
92995 D8RG18 PAC:15422242 Selaginella moellendorffii 563  
418417 D8S5M5 PAC:15406633 Selaginella moellendorffii 531  
122255 D8SPU2 PAC:15419074 Selaginella moellendorffii 423  
130418 D8T2D2 PAC:15421699 Selaginella moellendorffii 647  
419303 D8S8H4 PAC:15408771 Selaginella moellendorffii 1665  
114752 D8SDT1 PAC:15421376 Selaginella moellendorffii 294  
231245 D8RCX7 PAC:15415292 Selaginella moellendorffii 419  
428663 D8T3M1 PAC:15415590 Selaginella moellendorffii 480  
74713 D8QP68 PAC:15412093 Selaginella moellendorffii 495  
99251 D8RQJ4 PAC:15415093 Selaginella moellendorffii 456  
evm.TU.contig_43454.1 PAC:16431880 Carica papaya 220  
evm.model.supercontig_119.38 PAC:16406554 Carica papaya 567  
evm.model.supercontig_13.179 PAC:16407690 Carica papaya 439  
evm.model.supercontig_136.10 PAC:16408298 Carica papaya 318  
evm.model.supercontig_1431.2 PAC:16409022 Carica papaya 778  
evm.model.supercontig_258.12 PAC:16415002 Carica papaya 282  
evm.model.supercontig_26.176 PAC:16415112 Carica papaya 450  
evm.model.supercontig_285.2 PAC:16416068 Carica papaya 500  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID