Protein Domain : IPR002300

Type:  Domain Name:  Aminoacyl-tRNA synthetase, class Ia
Description:  The aminoacyl-tRNA synthetase (alsoknown as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.The class Ia aminoacyl-tRNA synthetases consist of the isoleucyl, methionyl, valyl, leucyl, cysteinyl, and arginyl-tRNA synthetases; the class Ib include the glutamyl and glutaminyl-tRNA synthetases, and the class Ic are the tyrosyl and tryptophanyl-tRNA synthetases[]. Short Name:  aa-tRNA-synth_Ia

0 Child Features

2 Contains

DB identifier Type Name
IPR009008 Domain Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR001412 Conserved_site Aminoacyl-tRNA synthetase, class I, conserved site

1 Cross References


3 Found Ins

DB identifier Type Name
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR002303 Family Valine-tRNA ligase
IPR020791 Family Leucine-tRNA ligase, archaeal

4 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR002300
GO:0004812 IPR002300
GO:0005524 IPR002300
GO:0006418 IPR002300

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
157130 D8SPD3 PAC:15409754 Selaginella moellendorffii 1103  
445517 D8SJ90 PAC:15420275 Selaginella moellendorffii 1155  
77212 D8QTN5 PAC:15417053 Selaginella moellendorffii 1096  
141956 D8QWX7 PAC:15413568 Selaginella moellendorffii 960  
154280 D8SCM5 PAC:15401882 Selaginella moellendorffii 496  
419576 D8S9D9 PAC:15410556 Selaginella moellendorffii 182  
153639 D8S9D7 PAC:15401914 Selaginella moellendorffii 1155  
426245 D8SVU0 PAC:15406519 Selaginella moellendorffii 305  
437676 D8QNT8 PAC:15419827 Selaginella moellendorffii 1707  
443981 D8S601 PAC:15417664 Selaginella moellendorffii 1031  
410808 D8RFX9 PAC:15408586 Selaginella moellendorffii 1108  
evm.TU.contig_44292.1 PAC:16431994 Carica papaya 53  
evm.model.supercontig_1.387 PAC:16404329 Carica papaya 618  
evm.model.supercontig_113.23 PAC:16406032 Carica papaya 1077  
evm.model.supercontig_116.46 PAC:16406303 Carica papaya 804  
evm.model.supercontig_152.47 PAC:16409632 Carica papaya 975  
evm.model.supercontig_16.173 PAC:16410022 Carica papaya 864  
evm.model.supercontig_2.74 PAC:16412864 Carica papaya 1095  
evm.model.supercontig_32.3 PAC:16417407 Carica papaya 531  
29585.m000579 B9SR18 PAC:16803143 Ricinus communis 523  
29657.m000469 B9SUT5 PAC:16804968 Ricinus communis 1175  
29726.m004043 B9RT52 PAC:16806754 Ricinus communis 1102  
29765.m000722 B9SKB0 PAC:16808191 Ricinus communis 1087  
29777.m000279 B9SWL0 PAC:16808339 Ricinus communis 1065  
29842.m003545 B9RXG5 PAC:16810678 Ricinus communis 960  
29876.m000251 B9SZE7 PAC:16811966 Ricinus communis 1087  
30169.m006337 B9RI23 PAC:16821138 Ricinus communis 111  
27451.m000252 B9SYX1 PAC:16798379 Ricinus communis 694  
Cucsa.166330.1 PAC:16966154 Cucumis sativus 1045  
Cucsa.010570.1 A0A0A0KQV7 PAC:16951296 Cucumis sativus 611  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID