Protein Domain : IPR004493

Type:  Family Name:  Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction.These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.Leucyl tRNA synthetase () is an alpha monomer that belongs to class Ia. There are two different families of leucyl-tRNA synthetases. This family includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases. Short Name:  Leu-tRNA-synth_Ia_arc/euk

1 Child Features

DB identifier Type Name
IPR020791 Family Leucine-tRNA ligase, archaeal

4 Contains

DB identifier Type Name
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR013155 Domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR009008 Domain Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR001412 Conserved_site Aminoacyl-tRNA synthetase, class I, conserved site

1 Cross References


0 Found In

5 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR004493
GO:0004823 IPR004493
GO:0005524 IPR004493
GO:0006429 IPR004493
GO:0005737 IPR004493

0 Parent Features

208 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
157130 D8SPD3 PAC:15409754 Selaginella moellendorffii 1103  
77212 D8QTN5 PAC:15417053 Selaginella moellendorffii 1096  
410808 D8RFX9 PAC:15408586 Selaginella moellendorffii 1108  
evm.model.supercontig_113.23 PAC:16406032 Carica papaya 1077  
29765.m000722 B9SKB0 PAC:16808191 Ricinus communis 1087  
29876.m000251 B9SZE7 PAC:16811966 Ricinus communis 1087  
Cucsa.226900.1 A0A0A0LV91 PAC:16969993 Cucumis sativus 1090  
Cucsa.226900.2 A0A0A0LV91 PAC:16969994 Cucumis sativus 1090  
Cucsa.226900.3 A0A0A0LV91 PAC:16969995 Cucumis sativus 1090  
Cucsa.226900.4 A0A0A0LV91 PAC:16969996 Cucumis sativus 1090  
orange1.1g039882m A0A067DHH7 PAC:18107191 Citrus sinensis 1142  
AT1G09620.1 F4I116 PAC:19651946 Arabidopsis thaliana 1091  
Thhalv10027096m V4MS93 PAC:20193026 Eutrema salsugineum 1078  
Thhalv10028099m V4NKW6 PAC:20189657 Eutrema salsugineum 809  
Thhalv10006633m V4L0R7 PAC:20188718 Eutrema salsugineum 1086  
Thhalv10009411m PAC:20185582 Eutrema salsugineum 1053  
Ciclev10000088m V4SVG7 PAC:20787292 Citrus clementina 1121  
Ciclev10000106m V4T5E1 PAC:20787293 Citrus clementina 1088  
Carubv10008146m R0GUQ8 PAC:20892382 Capsella rubella 1097  
Carubv10008148m R0IAV3 PAC:20892440 Capsella rubella 1095  
MDP0000856348 PAC:22660173 Malus domestica 1096  
MDP0000770037 PAC:22673024 Malus domestica 1096  
MDP0000810744 PAC:22659278 Malus domestica 1096  
MDP0000635945 PAC:22657500 Malus domestica 1096  
Lus10024704 PAC:23161630 Linum usitatissimum 1154  
Potri.004G226700.1 PAC:26989833 Populus trichocarpa 1171  
Potri.003G003900.1 PAC:26997363 Populus trichocarpa 1087  
Gorai.007G263900.1 A0A0D2SRK5 PAC:26778947 Gossypium raimondii 1087  
Gorai.007G263900.2 A0A0D2SRK5 PAC:26778948 Gossypium raimondii 1087  
mrna12369.1-v1.0-hybrid PAC:27267054 Fragaria vesca 1086  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID