Protein Domain : IPR015940

Type:  Domain Name:  Ubiquitin-associated domain
Description:  UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway, DNA excision-repair, and cell signalling via protein kinases []. The human homologue of yeast Rad23A is one example of a nucleotide excision-repair protein that contains both an internal and a C-terminal UBA domain. The solution structure of human Rad23A UBA(2) showed that the domain forms a compact three-helix bundle []. Comparison of the structures of UBA(1) and UBA(2) reveals that both form very similar folds and have a conserved large hydrophobic surface patch which may be a common protein-interacting surface present in diverse UBA domains. Evidence that ubiquitin binds to UBA domains leads to the prediction that the hydrophobic surface patch of UBA domains interacts with the hydrophobic surface on the five-stranded beta-sheet of ubiquitin [].This domain is similar in sequence to the N-terminal domain of translation elongation factor EF1B (or EF-Ts) from bacteria, mitochondria and chloroplasts []. Short Name:  UBA

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PS50030
PF00627
SM00165

3 Found Ins

DB identifier Type Name
IPR015496 Family Ubiquilin
IPR004806 Family UV excision repair protein Rad23
IPR016652 Family Ubiquitinyl hydrolase

0 GO Annotation

1 Parent Features

DB identifier Type Name
IPR009060 Domain UBA-like

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
140420 D8QTW6 PAC:15406653 Selaginella moellendorffii 413  
171198 D8RG44 PAC:15406719 Selaginella moellendorffii 536  
419654 D8S9L7 PAC:15411275 Selaginella moellendorffii 323  
443383 D8S0X6 PAC:15413120 Selaginella moellendorffii 409  
140411 D8QTV1 PAC:15406625 Selaginella moellendorffii 297  
154179 D8SC62 PAC:15423310 Selaginella moellendorffii 3545  
73901 D8QQC3 PAC:15410708 Selaginella moellendorffii 556  
80443 PAC:15405291 Selaginella moellendorffii 509  
82644 D8R1C4 PAC:15412760 Selaginella moellendorffii 385  
86216 D8R6K7 PAC:15421213 Selaginella moellendorffii 779  
95808 D8RKQ5 PAC:15407724 Selaginella moellendorffii 195  
233667 D8SCV6 PAC:15401861 Selaginella moellendorffii 499  
405547 D8QYY0 PAC:15413993 Selaginella moellendorffii 506  
77427 D8QS60 PAC:15418601 Selaginella moellendorffii 367  
evm.model.supercontig_3.37 PAC:16416668 Carica papaya 223  
evm.model.supercontig_1.181 PAC:16404101 Carica papaya 274  
evm.model.supercontig_12.20 PAC:16406748 Carica papaya 803  
evm.model.supercontig_12.91 PAC:16406935 Carica papaya 409  
evm.model.supercontig_14.127 PAC:16408622 Carica papaya 522  
evm.model.supercontig_159.27 PAC:16409918 Carica papaya 568  
evm.model.supercontig_20.203 PAC:16413008 Carica papaya 565  
evm.model.supercontig_21.42 PAC:16413553 Carica papaya 3387  
evm.model.supercontig_332.3 PAC:16417764 Carica papaya 548  
evm.model.supercontig_4.125 PAC:16419203 Carica papaya 194  
evm.model.supercontig_46.70 PAC:16420539 Carica papaya 562  
evm.model.supercontig_48.83 PAC:16420946 Carica papaya 969  
evm.model.supercontig_535.2 PAC:16422347 Carica papaya 559  
evm.model.supercontig_68.39 PAC:16424837 Carica papaya 274  
evm.model.supercontig_8.133 PAC:16426412 Carica papaya 252  
evm.model.supercontig_85.5 PAC:16427485 Carica papaya 411  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12079361
            9846873
            8871400
            8596629