Protein Domain : IPR011992

Type:  Domain Name:  EF-hand domain pair
Description:  This domain consists of a duplication of two EF-hand units, where each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain [, ]. These include: calbindin D9K, S100 proteins such as calcyclin, polcalcin phl p 7 (a calcium-binding pollen allergen), osteonectin, parvalbumin, calmodulin []family of proteins (troponin C, caltractin, cdc4p, myosin essential chain, calcineurin, recoverin, neurocalcin), plasmodial-specific CaII-binding protein Cbp40, penta-EF-Hand proteins [](sorcin, grancalcin, calpain), as well as multidomain proteins such as phosphoinositide-specific phospholipase C, dystrophin, Cb1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins. Short Name:  EF-hand-dom_pair

3 Child Features

DB identifier Type Name
IPR015359 Domain Phosphoinositide-specific phospholipase C, EF-hand-like domain
IPR019577 Domain SPARC/Testican, calcium-binding domain
IPR014741 Domain Adaptor protein Cbl, EF hand-like

11 Contains

DB identifier Type Name
IPR002048 Domain EF-hand domain
IPR013623 Domain NADPH oxidase Respiratory burst
IPR013567 Domain EF hand associated, type-2
IPR013566 Domain EF hand associated, type-1
IPR013787 Domain S100/CaBP-9k-type, calcium binding, subdomain
IPR001999 Conserved_site Osteonectin-like, conserved site
IPR018247 Binding_site EF-Hand 1, calcium-binding site
IPR014837 Domain EF-hand, Ca insensitive
IPR015154 Domain EF-hand domain, type 2
IPR015153 Domain EF-hand domain, type 1
IPR001751 Conserved_site S100/Calbindin-D9k, conserved site

2 Cross Referencess

Identifier
PF13499
G3DSA:1.10.238.10

10 Found Ins

DB identifier Type Name
IPR001217 Family Transcription factor STAT
IPR008080 Family Parvalbumin
IPR016359 Family SPARC-like protein 1
IPR013333 Family Ryanodine receptor
IPR015757 Family Calcineurin B protein
IPR015754 Family Calcium binding protein 2
IPR015756 Family Guanylate cyclase activating protein 2
IPR013801 Domain STAT transcription factor, DNA-binding
IPR017432 Family Distrobrevin
IPR016344 Family Dystrophin

0 GO Annotation

0 Parent Features

24186 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
133830 D8T7J8 PAC:15411403 Selaginella moellendorffii 421  
148957 D8RQ38 PAC:15411715 Selaginella moellendorffii 470  
173355 D8RQC7 PAC:15414147 Selaginella moellendorffii 640  
183465 D8SX41 PAC:15421947 Selaginella moellendorffii 809  
231127 PAC:15414521 Selaginella moellendorffii 530  
233632 D8SCB9 PAC:15401765 Selaginella moellendorffii 148  
233792 D8SE62 PAC:15402624 Selaginella moellendorffii 139  
271951 D8SX15 PAC:15404643 Selaginella moellendorffii 572  
272115 C4P7X7 PAC:15401422 Selaginella moellendorffii 226  
403322 D8QTT2 PAC:15406407 Selaginella moellendorffii 415  
403502 D8QRM0 PAC:15407833 Selaginella moellendorffii 103  
404996 D8QY19 PAC:15414221 Selaginella moellendorffii 424  
407440 D8R5L9 PAC:15418996 Selaginella moellendorffii 354  
417593 D8S2Y7 PAC:15404595 Selaginella moellendorffii 222  
417597 D8S2Z1 PAC:15404601 Selaginella moellendorffii 137  
419239 D8S8A5 PAC:15408011 Selaginella moellendorffii 296  
424392 D8SPR0 PAC:15401566 Selaginella moellendorffii 224  
428633 D8T3H2 PAC:15415527 Selaginella moellendorffii 412  
443360 D8S0P5 PAC:15413057 Selaginella moellendorffii 1031  
443463 D8S1P3 PAC:15413880 Selaginella moellendorffii 620  
59528 D8RLC2 PAC:15410857 Selaginella moellendorffii 121  
54873 PAC:15420903 Selaginella moellendorffii 311  
56048 PAC:15420585 Selaginella moellendorffii 290  
76965 D8QSR8 PAC:15419584 Selaginella moellendorffii 546  
83164 D8R0W8 PAC:15411910 Selaginella moellendorffii 595  
85336 D8R568 PAC:15419203 Selaginella moellendorffii 541  
96597 D8RL53 PAC:15408604 Selaginella moellendorffii 159  
99105 PAC:15414254 Selaginella moellendorffii 331  
406923 D8R3D0 PAC:15419810 Selaginella moellendorffii 552  
105020 D8RYX6 PAC:15411844 Selaginella moellendorffii 531  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12111723
            11114499
            12445459
            12542690