Protein Domain : IPR007087

Type:  Domain Name:  Zinc finger, C2H2
Description:  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger: #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C], where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [].This entry represents the classical C2H2 zinc finger domain. Short Name:  Znf_C2H2

0 Child Features

1 Contains

DB identifier Type Name
IPR015318 Domain Zinc finger, GAGA-binding factor

3 Cross Referencess

Identifier
PS50157
PF00096
PS00028

13 Found Ins

DB identifier Type Name
IPR013087 Domain Zinc finger C2H2-type/integrase DNA-binding domain
IPR004595 Domain TFIIH C1-like domain
IPR007042 Domain Arsenite-resistance protein 2
IPR009170 Family Predicted retinoblastoma binding protein (RIZ)
IPR017126 Family PR-domain zinc finger protein PRDM12
IPR017125 Family PR-domain zinc finger protein PRDM5
IPR017124 Family PR-domain zinc finger protein PRDM4
IPR017114 Family Transcription factor yin/yang
IPR017083 Family RNA editing complex, nuclease subunit MP42
IPR017086 Family RNA editing complex, structural subunit MP63
IPR017085 Family RNA editing complex, structural subunit MP81
IPR016378 Family Transcription factor cyclic AMP-dependent, CRE-BP1-type
IPR016766 Family Transcription regulator Tri6

1 GO Annotation

GO Term Gene Name Organism
GO:0046872 IPR007087

1 Parent Features

DB identifier Type Name
IPR015880 Domain Zinc finger, C2H2-like

15391 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
117908 D8SIR0 PAC:15409370 Selaginella moellendorffii 129  
149266 D8RRS2 PAC:15409270 Selaginella moellendorffii 94  
405132 D8QYI2 PAC:15410834 Selaginella moellendorffii 181  
405772 PAC:15415542 Selaginella moellendorffii 801  
405785 D8QZP7 PAC:15415568 Selaginella moellendorffii 474  
411620 D8RII3 PAC:15410103 Selaginella moellendorffii 345  
414957 D8RU52 PAC:15421146 Selaginella moellendorffii 157  
421852 D8SGK0 PAC:15418927 Selaginella moellendorffii 247  
425147 D8SS58 PAC:15402813 Selaginella moellendorffii 473  
430201 PAC:15418448 Selaginella moellendorffii 186  
438136 D8QUC4 PAC:15418855 Selaginella moellendorffii 1267  
57114 D8SEV6 PAC:15401878 Selaginella moellendorffii 151  
58350 D8S5N8 PAC:15406379 Selaginella moellendorffii 172  
80646 D8QY40 PAC:15406828 Selaginella moellendorffii 108  
101058 D8RTH9 PAC:15422417 Selaginella moellendorffii 398  
110681 D8S7B2 PAC:15409085 Selaginella moellendorffii 206  
28310 PAC:15406966 Selaginella moellendorffii 90  
236040 D8T4G9 PAC:15405942 Selaginella moellendorffii 359  
268776 D8SK49 PAC:15416487 Selaginella moellendorffii 408  
404286 D8QUV3 PAC:15408699 Selaginella moellendorffii 1184  
405526 D8QYV6 PAC:15413952 Selaginella moellendorffii 662  
410097 D8RDG5 PAC:15402664 Selaginella moellendorffii 273  
9104 D8RTP8 PAC:15405667 Selaginella moellendorffii 85  
9108 D8S4W0 PAC:15405673 Selaginella moellendorffii 85  
416804 D8S0G6 PAC:15403757 Selaginella moellendorffii 362  
424602 PAC:15403587 Selaginella moellendorffii 124  
439488 D8R5F2 PAC:15401839 Selaginella moellendorffii 846  
440762 D8RE62 PAC:15407176 Selaginella moellendorffii 1529  
56696 D8S6I2 PAC:15402894 Selaginella moellendorffii 260  
93509 D8RHP2 PAC:15421921 Selaginella moellendorffii 145  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12665246
            15718139
            17210253
            15963892
            10529348
            11179890
            12683994