Protein Domain : IPR011598

Type:  Domain Name:  Myc-type, basic helix-loop-helix (bHLH) domain
Description:  A number of eukaryotic proteins, which probably are sequence specific DNA-binding proteins that act as transcription factors, share a conserved domainof 40 to 50 amino acid residues. It has been proposed []that this domain isformed of two amphipathic helices joined by a variable length linker regionthat could form a loop. This 'helix-loop-helix' (HLH) domain mediates proteindimerization and has been found in the proteins listed below []. Mostof these proteins have an extra basic region of about 15 amino acid residuesthat is adjacent to the HLH domain and specifically binds to DNA. They arerefered as basic helix-loop-helix proteins (bHLH), and are classified in twogroups: class A (ubiquitous) and class B (tissue-specific). Members of thebHLH family bind variations on the core sequence 'CANNTG', also refered to asthe E-box motif. The homo- or heterodimerization mediated by the HLH domain isindependent of, but necessary for DNA binding, as two basic regions arerequired for DNA binding activity. The HLH proteins lacking the basic domain(Emc, Id) function as negative regulators, since they form heterodimers, butfail to bind DNA. The hairy-related proteins (hairy, E(spl), deadpan) alsorepress transcription although they can bind DNA. The proteins of thissubfamily act together with co-repressor proteins, like groucho, through theirC-terminal motif WRPW.Proteins containing a HLH domain include:The myc family of cellular oncogenes [], which is currently known to contain four members: c-myc, N-myc, L-myc, and B-myc. The myc genes are thought to play a role in cellular differentiation and proliferation.Proteins involved in myogenesis (the induction of muscle cells). In mammals MyoD1 (Myf-3), myogenin (Myf-4), Myf-5, and Myf-6 (Mrf4 or herculin), in birds CMD1 (QMF-1), in Xenopus MyoD and MF25, in Caenorhabditis elegans CeMyoD, and in Drosophila nautilus (nau).Vertebrate proteins that bind specific DNA sequences ('E boxes') in various immunoglobulin chains enhancers: E2A or ITF-1 (E12/pan-2 and E47/pan-1), ITF-2 (tcf4), TFE3, and TFEB.Vertebrate neurogenic differentiation factor 1 that acts as differentiation factor during neurogenesis.Vertebrate MAX protein, a transcription regulator that forms a sequence- specific DNA-binding protein complex with myc or mad.Vertebrate Max Interacting Protein 1 (MXI1 protein) which acts as a transcriptional repressor and may antagonize myc transcriptional activity by competing for max.Proteins of the bHLH/PAS superfamily which are transcriptional activators. In mammals, AH receptor nuclear translocator (ARNT), single-minded homologues (SIM1 and SIM2), hypoxia-inducible factor 1 alpha (HIF1A), AH receptor (AHR), neuronal pas domain proteins (NPAS1 and NPAS2), endothelial pas domain protein 1 (EPAS1), mouse ARNT2, and human BMAL1. In Drosophila, single-minded (SIM), AH receptor nuclear translocator (ARNT), trachealess protein (TRH), and similar protein (SIMA).Mammalian transcription factors HES, which repress transcription by acting on two types of DNA sequences, the E box and the N box.Mammalian MAD protein (max dimerizer) which acts as transcriptional repressor and may antagonize myc transcriptional activity by competing for max.Mammalian Upstream Stimulatory Factor 1 and 2 (USF1 and USF2), which bind to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters.Human lyl-1 protein; which is involved, by chromosomal translocation, in T- cell leukemia.Human transcription factor AP-4.Mouse helix-loop-helix proteins MATH-1 and MATH-2 which activate E box- dependent transcription in collaboration with E47.Mammalian stem cell protein (SCL) (also known as tal1), a protein which may play an important role in hemopoietic differentiation. SCL is involved, by chromosomal translocation, in stem-cell leukemia.Mammalian proteins Id1 to Id4 []. Id (inhibitor of DNA binding) proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting binding to DNA.Drosophila extra-macrochaetae (emc) protein, which participates in sensory organ patterning by antagonizing the neurogenic activity of the achaete- scute complex. Emc is the homologue of mammalian Id proteins.Human Sterol Regulatory Element Binding Protein 1 (SREBP-1), a transcriptional activator that binds to the sterol regulatory element 1 (SRE-1) found in the flanking region of the LDLR gene and in other genes.Drosophila achaete-scute (AS-C) complex proteins T3 (l'sc), T4 (scute), T5 (achaete) and T8 (asense). The AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.Mammalian homologues of achaete-scute proteins, the MASH-1 and MASH-2 proteins.Drosophila atonal protein (ato) which is involved in neurogenesis. Short Name:  bHLH_dom

0 Child Features

0 Contains

5 Cross Referencess

Identifier
SSF47459
SM00353
PF00010
PS50888
G3DSA:4.10.280.10

6 Found Ins

DB identifier Type Name
IPR015660 Family Achaete-scute transcription factor-related
IPR017426 Family Nuclear receptor coactivator
IPR002418 Family Transcription regulator Myc
IPR016637 Family Transcription factor, basic helix-loop-helix, NeuroD
IPR001067 Family Nuclear translocator
IPR015789 Family Twist-related

1 GO Annotation

GO Term Gene Name Organism
GO:0046983 IPR011598

0 Parent Features

20731 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
117274 D8SHL1 PAC:15404072 Selaginella moellendorffii 108  
128445 D8SZ78 PAC:15415780 Selaginella moellendorffii 61  
131087 PAC:15421737 Selaginella moellendorffii 174  
16039 D8RRH4 PAC:15414192 Selaginella moellendorffii 169  
402301 D8QQ77 PAC:15403384 Selaginella moellendorffii 638  
408928 D8R8X3 PAC:15403263 Selaginella moellendorffii 422  
409950 D8RCZ7 PAC:15406287 Selaginella moellendorffii 275  
409967 D8RD17 PAC:15406316 Selaginella moellendorffii 499  
412326 D8RKT0 PAC:15410775 Selaginella moellendorffii 258  
412681 D8RL49 PAC:15413217 Selaginella moellendorffii 188  
413316 D8RP23 PAC:15413686 Selaginella moellendorffii 364  
419388 D8S8S8 PAC:15408972 Selaginella moellendorffii 335  
421249 D8SEH0 PAC:15414359 Selaginella moellendorffii 324  
424152 D8SNZ7 PAC:15422189 Selaginella moellendorffii 511  
445783 D8SLD3 PAC:15421871 Selaginella moellendorffii 272  
75047 D8QPQ4 PAC:15409697 Selaginella moellendorffii 192  
77288 D8QSQ4 PAC:15417200 Selaginella moellendorffii 175  
93546 D8RGJ6 PAC:15421991 Selaginella moellendorffii 125  
118904 D8SK13 PAC:15412311 Selaginella moellendorffii 89  
402536 D8QQZ5 PAC:15404985 Selaginella moellendorffii 273  
165311 D8QU30 PAC:15412634 Selaginella moellendorffii 246  
28262 D8RPY7 PAC:15406370 Selaginella moellendorffii 90  
24892 D8R343 PAC:15421579 Selaginella moellendorffii 143  
165556 D8QU30 PAC:15414307 Selaginella moellendorffii 246  
418491 D8S5W0 PAC:15406797 Selaginella moellendorffii 298  
34848 D8RNU5 PAC:15406414 Selaginella moellendorffii 154  
408741 D8R9T5 PAC:15401845 Selaginella moellendorffii 181  
442874 D8RWT9 PAC:15414042 Selaginella moellendorffii 684  
443113 D8RYP6 PAC:15411404 Selaginella moellendorffii 512  
444782 D8SCY3 PAC:15419094 Selaginella moellendorffii 443  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2493990
            2175254
            1521738
            8139914