Protein Domain : IPR013026

Type:  Domain Name:  Tetratricopeptide repeat-containing domain
Description:  The tetratrico peptide repeat region (TPR) is a structural motif present in a wide range of proteins [, , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes []. The TPR motifconsists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs canbe dispersed in the protein sequence. Sequence alignment of the TPR domains reveals aconsensus sequence defined by a pattern of small and large amino acids. TPR motifs have beenidentified in various different organisms, ranging from bacteria to humans. Proteins containingTPRs are involved in a variety of biological processes, such as cell cycle regulation,transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis andprotein folding.The X-ray structure of a domain containing three TPRs from protein phosphatase 5 revealed thatTPR adopts a helix-turn-helix arrangement, with adjacent TPR motifs packing in a parallelfashion, resulting in a spiral of repeating anti-parallel alpha-helices []. The two helices are denotedhelix A and helix B. The packing angle between helix A and helix B is ~24 degrees within asingle TPR and generates a right-handed superhelical shape. Helix A interacts with helix B andwith helix A' of the next TPR. Two protein surfaces are generated: the inner concave surface iscontributed to mainly by residue on helices A, and the other surface presents residues from bothhelices A and B. Short Name:  TPR-contain_dom

0 Child Features

6 Contains

DB identifier Type Name
IPR013105 Repeat Tetratricopeptide repeat 2
IPR011717 Repeat Tetratricopeptide TPR-4
IPR001440 Repeat Tetratricopeptide repeat 1
IPR011716 Repeat Tetratricopeptide TPR-3
IPR019544 Domain Tetratricopeptide, SHNi-TPR domain
IPR015792 Repeat Kinesin light chain repeat

1 Cross References


17 Found Ins

DB identifier Type Name
IPR011990 Domain Tetratricopeptide-like helical domain
IPR021183 Family N-terminal acetyltransferase A, auxiliary subunit
IPR002151 Family Kinesin light chain
IPR011236 Family Serine/threonine protein phosphatase 5
IPR001237 Family 43kDa postsynaptic protein
IPR005687 Family Mitochondrial outer membrane translocase complex, subunit Tom70
IPR016931 Family Uncharacterised conserved protein UCP029658, TPR
IPR016684 Family Type III secretion system chaperone, YscY
IPR014266 Family PEP-CTERM system TPR-repeat lipoprotein, putative
IPR014562 Family Uncharacterised conserved protein UCP030959, divergent TPR repeat-containing
IPR014162 Domain Tol-Pal system, YbgF
IPR013360 Family Pilus biogenesis/stability type IV, PilW
IPR003921 Family Cellulose synthase, subunit C
IPR016379 Family Type III secretion system, low calcium response, chaperone LcrH/SycD, subgroup
IPR005415 Family Type III secretion system, low calcium response, chaperone LcrH/SycD
IPR014460 Family Signal transduction response regulator, predicted, VieB
IPR014596 Family Uncharacterised conserved protein UCP035836

1 GO Annotation

GO Term Gene Name Organism
GO:0005515 IPR013026

0 Parent Features

21987 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
107379 D8S3B5 PAC:15420062 Selaginella moellendorffii 87  
115934 D8SFV6 PAC:15403473 Selaginella moellendorffii 1076  
123922 D8SSG2 PAC:15404802 Selaginella moellendorffii 668  
149863 D8RTU4 PAC:15413967 Selaginella moellendorffii 1041  
160429 D8T2I3 PAC:15421037 Selaginella moellendorffii 236  
183465 D8SX41 PAC:15421947 Selaginella moellendorffii 809  
272183 D8T687 PAC:15401589 Selaginella moellendorffii 538  
404439 D8QVB9 PAC:15410206 Selaginella moellendorffii 689  
406722 D8R189 PAC:15418290 Selaginella moellendorffii 355  
410232 D8RE28 PAC:15404033 Selaginella moellendorffii 354  
411103 D8RGL0 PAC:15406167 Selaginella moellendorffii 860  
412702 D8RL78 PAC:15413814 Selaginella moellendorffii 140  
416844 D8S0K8 PAC:15403837 Selaginella moellendorffii 309  
417136 D8S1H3 PAC:15401489 Selaginella moellendorffii 588  
419030 D8S7L0 PAC:15406530 Selaginella moellendorffii 733  
42040 D8SVN0 PAC:15401643 Selaginella moellendorffii 593  
421229 D8SEE9 PAC:15414309 Selaginella moellendorffii 387  
428314 D8T2F3 PAC:15413182 Selaginella moellendorffii 243  
431495 D8TCU6 PAC:15422993 Selaginella moellendorffii 442  
438270 D8QVI4 PAC:15419699 Selaginella moellendorffii 1912  
439259 D8R357 PAC:15422503 Selaginella moellendorffii 581  
439621 D8R6I2 PAC:15403132 Selaginella moellendorffii 326  
443450 D8S1K0 PAC:15413838 Selaginella moellendorffii 567  
444100 D8S6F9 PAC:15414330 Selaginella moellendorffii 1047  
61985 D8RHP3 PAC:15420136 Selaginella moellendorffii 408  
74711 D8QPQ0 PAC:15412089 Selaginella moellendorffii 281  
79168 D8QUI0 PAC:15422117 Selaginella moellendorffii 695  
80159 PAC:15403009 Selaginella moellendorffii 241  
82681 D8R0W4 PAC:15412842 Selaginella moellendorffii 373  
90481 D8RCU6 PAC:15412673 Selaginella moellendorffii 424  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID