Protein Domain : IPR000048

Type:  Binding_site Name:  IQ motif, EF-hand binding site
Description:  The IQ motif is an extremely basic unit of about 23 amino acids, whose conserved core usually fits the consensus A-x(3)-I-Q-x(2)-F-R-x(4)-K-K. The IQ motif, which can be present in one or more copies, serves as a binding site for different EF-hand proteins including the essential and regulatory myosin light chains, calmodulin (CaM), and CaM-like proteins [, ].Many IQ motifs are protein kinase C (PKC) phosphorylation sites [, ].Resolution of the 3D structure of scallop myosin has shown that the IQ motif forms a basic amphipathic helix [].Some proteins known to contain an IQ motif are listed below:A number of conventional and unconventional myosins.Neuromodulin (GAP-43). This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.Neurogranin (NG/p17). Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling.Sperm surface protein Sp17.Ras GTPase-activating-like protein IQGAP1. IQGAP1 contains 4 IQ motifs.This entry covers the entire IQ motif. Short Name:  IQ_motif_EF-hand-BS

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PS50096
SM00015
PF00612

7 Found Ins

DB identifier Type Name
IPR012105 Family Sperm surface protein Sp17
IPR001696 Family Voltage gated sodium channel, alpha subunit
IPR008052 Family Voltage gated sodium channel, alpha-4 subunit, mammalian
IPR008053 Family Voltage gated sodium channel, alpha-5 subunit
IPR008054 Family Voltage gated sodium channel, alpha-8 subunit
IPR001422 Family Neuromodulin (GAP-43)
IPR012008 Family Serine/threonine-protein phosphatase with EF-hands

1 GO Annotation

GO Term Gene Name Organism
GO:0005515 IPR000048

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
106391 D8S1Q0 PAC:15417178 Selaginella moellendorffii 625  
113786 D8SCK7 PAC:15418666 Selaginella moellendorffii 726  
407922 D8R572 PAC:15422687 Selaginella moellendorffii 586  
418617 D8S6L5 PAC:15408111 Selaginella moellendorffii 596  
438938 D8R0K7 PAC:15402560 Selaginella moellendorffii 499  
441008 D8RFZ5 PAC:15404621 Selaginella moellendorffii 603  
67789 D8RGM4 PAC:15413954 Selaginella moellendorffii 170  
447292 D8SYA8 PAC:15401642 Selaginella moellendorffii 204  
447811 D8T2F4 PAC:15406032 Selaginella moellendorffii 375  
6054 D8SUV2 PAC:15418645 Selaginella moellendorffii 86  
174533 D8RV10 PAC:15418455 Selaginella moellendorffii 1521  
402187 D8QPV6 PAC:15402121 Selaginella moellendorffii 484  
403358 D8QTX3 PAC:15406462 Selaginella moellendorffii 461  
410247 D8RE45 PAC:15404064 Selaginella moellendorffii 559  
441667 D8RLU7 PAC:15409450 Selaginella moellendorffii 982  
443711 D8S3T4 PAC:15416004 Selaginella moellendorffii 637  
77935 D8QUK1 PAC:15422348 Selaginella moellendorffii 543  
98074 D8RP15 PAC:15410683 Selaginella moellendorffii 1081  
418826 D8S6H8 PAC:15409744 Selaginella moellendorffii 387  
419634 D8S9J6 PAC:15411245 Selaginella moellendorffii 1459  
431540 D8TD00 PAC:15401404 Selaginella moellendorffii 750  
431994 D8TEM5 PAC:15404503 Selaginella moellendorffii 787  
103418 D8RWM0 PAC:15408946 Selaginella moellendorffii 1045  
437903 D8QRU1 PAC:15421861 Selaginella moellendorffii 899  
230820 D8R675 PAC:15416869 Selaginella moellendorffii 1498  
89324 D8RB40 PAC:15408478 Selaginella moellendorffii 663  
68032 D8RBN5 PAC:15411305 Selaginella moellendorffii 180  
416955 D8S0X3 PAC:15404646 Selaginella moellendorffii 378  
evm.model.supercontig_3.146 PAC:16416420 Carica papaya 521  
evm.model.supercontig_3.315 PAC:16416608 Carica papaya 409  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9141499
            8127365
            1558751
            1824695
            8424932