Protein Domain : IPR023214

Type:  Domain Name:  HAD-like domain
Description:  The haloacid dehydrogenase (HAD) superfamily includes phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification[].Crystal structures of proteins from the HAD superfamily show that these proteins all share a conserved alpha/beta-domain classified as a hydrolase fold, which is similar to the Rossmann fold []. This conserved domain usually contains an insertion (sub)domain. For example, the crystal structure of a phosphoglycolate phosphatase from Thermoplasma acidophilum []revealed two distinct domains, a larger core domain and a smaller cap domain. The large domain is composed of a centrally located five-stranded parallel beta-sheet with strand order S10, S9, S8, S1, S2 and a small beta-hairpin, strands S3 andS4. This central sheet is flanked by a set of three aplha-helices on one side and two helices on the other. The topology of the large domain is conserved; however, structural variation is observed in the smaller domain among the different functional classes of the haloacid dehalogenase superfamily.This entry represents the large domain with conserved topology among the HAD superfamily. Short Name:  HAD-like_dom

3 Child Features

DB identifier Type Name
IPR023299 Domain P-type ATPase, cytoplasmic domain N
IPR006549 Domain HAD-superfamily hydrolase,subfamily IIIA
IPR011945 Domain Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal

0 Contains

5 Cross Referencess

Identifier
G3DSA:3.40.50.1000
PF00702
PF08282
PF13419
SSF56784

0 Found In

0 GO Annotation

0 Parent Features

25128 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
104829 D8RYS7 PAC:15415048 Selaginella moellendorffii 286  
105991 D8S0Q9 PAC:15418871 Selaginella moellendorffii 300  
115253 D8SER1 PAC:15420593 Selaginella moellendorffii 168  
120943 D8SN47 PAC:15418501 Selaginella moellendorffii 165  
122967 D8SRI3 PAC:15402060 Selaginella moellendorffii 198  
131171 D8T3J4 PAC:15422507 Selaginella moellendorffii 206  
131775 D8T4R8 PAC:15404725 Selaginella moellendorffii 213  
166180 D8QWP4 PAC:15414249 Selaginella moellendorffii 1039  
170407 D8RD54 PAC:15405866 Selaginella moellendorffii 1047  
171410 D8RGT1 PAC:15408825 Selaginella moellendorffii 885  
184345 D8T0H9 PAC:15401819 Selaginella moellendorffii 890  
231359 D8REZ4 PAC:15416074 Selaginella moellendorffii 924  
233008 PAC:15419447 Selaginella moellendorffii 480  
233432 D8S8Z1 PAC:15422528 Selaginella moellendorffii 333  
411029 D8RHS4 PAC:15405447 Selaginella moellendorffii 346  
411169 D8RGS7 PAC:15406333 Selaginella moellendorffii 333  
417095 D8S1C3 PAC:15423111 Selaginella moellendorffii 245  
419773 D8S9Z7 PAC:15412046 Selaginella moellendorffii 523  
421682 D8SG14 PAC:15417432 Selaginella moellendorffii 369  
424001 D8SNH0 PAC:15421308 Selaginella moellendorffii 193  
424005 D8SNH4 PAC:15421318 Selaginella moellendorffii 199  
424076 D8SNQ7 PAC:15421459 Selaginella moellendorffii 147  
431271 D8TC30 PAC:15421408 Selaginella moellendorffii 295  
431418 D8TCK0 PAC:15422829 Selaginella moellendorffii 684  
439526 D8R5P0 PAC:15402413 Selaginella moellendorffii 1246  
443858 D8S4Y2 PAC:15416821 Selaginella moellendorffii 742  
445084 D8SFF7 PAC:15416569 Selaginella moellendorffii 847  
447828 D8T2L6 PAC:15406060 Selaginella moellendorffii 379  
60690 D8QRZ3 PAC:15414992 Selaginella moellendorffii 696  
74272 D8QQ47 PAC:15408325 Selaginella moellendorffii 309  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7966317
            14555659