Protein Domain : IPR020636

Type:  Family Name:  Calcium/calmodulin-dependent/calcium-dependent protein kinase
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].The divalent cation calcium (Ca2+) is one of the most widely utilised second messengers in cellular signaling. Many of the second messenger effects of Ca2+ aremediated through the ubiquitous Ca2+ sensing protein, calmodulin (CaM). CaM has no enzymatic activity as such, and its function is to integrate the Ca2+ signal and transduce it to other downstream enzymes, like the calmodulin-dependent kinases [].This entry includes both type I and type II calcium/calmodulin-dependent protein kinases [], as well as plant calcium-dependent protein kinases, which may also play a role in signal transduction pathways that involve calcium as a second messenger []. Short Name:  Ca/CaM-dep_Ca-dep_prot_Kinase

1 Child Features

DB identifier Type Name
IPR002291 Family Phosphorylase kinase, gamma catalytic subunit

8 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR018451 Domain NAF/FISL domain
IPR004041 Domain NAF domain
IPR013543 Domain Calcium/calmodulin-dependent protein kinase II, association-domain
IPR000959 Domain POLO box duplicated domain
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References


0 Found In

0 GO Annotation

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
101524 D8RSZ6 PAC:15403794 Selaginella moellendorffii 221  
110333 D8S7C8 PAC:15406643 Selaginella moellendorffii 256  
110515 D8S7B9 PAC:15408061 Selaginella moellendorffii 256  
3976 D8RFV7 PAC:15416799 Selaginella moellendorffii 154  
409871 D8RCR1 PAC:15405550 Selaginella moellendorffii 250  
110007 D8S6Q9 PAC:15404223 Selaginella moellendorffii 215  
110347 D8S7C3 PAC:15406677 Selaginella moellendorffii 256  
110745 D8S7C4 PAC:15409765 Selaginella moellendorffii 256  
404155 D8QUF9 PAC:15407809 Selaginella moellendorffii 397  
404156 D8QUG0 PAC:15407810 Selaginella moellendorffii 453  
8322 D8QUH1 PAC:15404265 Selaginella moellendorffii 101  
8351 D8RBF4 PAC:15404335 Selaginella moellendorffii 84  
413628 D8RQW3 PAC:15415997 Selaginella moellendorffii 224  
4154 D8RFR2 PAC:15413599 Selaginella moellendorffii 180  
416650 D8RZZ3 PAC:15402391 Selaginella moellendorffii 238  
416658 D8S001 PAC:15402404 Selaginella moellendorffii 208  
430503 D8T9L9 PAC:15420730 Selaginella moellendorffii 398  
5036 D8SZ45 PAC:15415713 Selaginella moellendorffii 149  
8330 D8R421 PAC:15404284 Selaginella moellendorffii 98  
8334 D8RPQ9 PAC:15404286 Selaginella moellendorffii 98  
90245 D8RCF6 PAC:15411115 Selaginella moellendorffii 150  
119400 D8SKL3 PAC:15411429 Selaginella moellendorffii 278  
121793 D8SP62 PAC:15420009 Selaginella moellendorffii 219  
111673 D8S8Z9 PAC:15412013 Selaginella moellendorffii 288  
15599 D8R518 PAC:15415171 Selaginella moellendorffii 187  
35928 D8R2S8 PAC:15410126 Selaginella moellendorffii 182  
5210 D8SZ54 PAC:15417149 Selaginella moellendorffii 176  
8332 D8RZZ6 PAC:15404285 Selaginella moellendorffii 98  
8335 D8RZY8 PAC:15404287 Selaginella moellendorffii 98  
evm.TU.contig_42087.1 PAC:16431691 Carica papaya 395  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID