Protein Domain : IPR002290

Type:  Domain Name:  Serine/threonine/dual specificity protein kinase, catalytic domain
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , ]are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme [].This entry represents the protein kinase catalytic domain found in a number of serine/threonine-protein kinases and dual specificity protein kinases. Short Name:  Ser/Thr_dual-sp_kinase

0 Child Features

3 Contains

DB identifier Type Name
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site
IPR003527 Conserved_site Mitogen-activated protein (MAP) kinase, conserved site

1 Cross References

Identifier
SM00220

29 Found Ins

DB identifier Type Name
IPR020636 Family Calcium/calmodulin-dependent/calcium-dependent protein kinase
IPR017348 Family Serine/threonine-protein kinase pim-1/2/3
IPR020679 Family Serine/threonine-protein kinase Tda1
IPR020675 Family Myosin light chain kinase-related
IPR015725 Family Telokin/Myosin light chain kinase
IPR015726 Family Serine/threonine protein kinase, striated muscle-specific
IPR020676 Family Death-associated protein kinase 1
IPR020684 Family Rho-associated protein kinase 1/2
IPR020682 Family Obscurin-myosin light chain kinase
IPR021160 Family Mitogen-activated protein (MAP) kinase kinase kinase kinase
IPR016237 Family Serine/threonine-protein kinase, Ulk1/Ulk2
IPR016242 Family Serine/threonine-protein kinase Mps1
IPR017090 Family Serine/threonine-protein kinase, SIK1/2
IPR017184 Family Serine/threonine-protein kinase Unc-51
IPR017239 Family Mitogen-activated protein (MAP) kinase kinase kinase Ste11, Cryptococcus
IPR008350 Family Mitogen-activatedprotein (MAP) kinase, ERK3/4
IPR002291 Family Phosphorylase kinase, gamma catalytic subunit
IPR020658 Family Serine/threonine-protein kinase Plk3
IPR002374 Family cGMP-dependent kinase
IPR016256 Family Serine/threonine-protein kinase Rad53
IPR000239 Family GPCR kinase
IPR015727 Family Protein kinase C mu-related
IPR014376 Family Protein kinase C, delta/epsilon/eta/theta types
IPR017405 Family Citron Rho-interacting kinase
IPR012233 Family Protein kinase C
IPR016238 Family Ribosomal protein S6 kinase
IPR016239 Family Ribosomal protein S6 kinase II
IPR014375 Family Protein kinase C, alpha/beta/gamma types
IPR017240 Family Mitogen-activated protein (MAP) kinase kinase kinase Ssk2/Ssk22

3 GO Annotations

GO Term Gene Name Organism
GO:0004672 IPR002290
GO:0005524 IPR002290
GO:0006468 IPR002290

1 Parent Features

DB identifier Type Name
IPR000719 Domain Protein kinase domain

41776 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
27379 D8QXH0 PAC:15404180 Selaginella moellendorffii 185  
101192 PAC:15423268 Selaginella moellendorffii 333  
101524 D8RSZ6 PAC:15403794 Selaginella moellendorffii 221  
103506 D8RWQ7 PAC:15409702 Selaginella moellendorffii 455  
109677 D8S6U3 PAC:15405823 Selaginella moellendorffii 353  
10499 D8SYB4 PAC:15421970 Selaginella moellendorffii 675  
112714 D8SA18 PAC:15415612 Selaginella moellendorffii 169  
122408 D8SQ96 PAC:15420456 Selaginella moellendorffii 724  
131164 D8T3L4 PAC:15422479 Selaginella moellendorffii 384  
135200 D8T9X8 PAC:15412584 Selaginella moellendorffii 217  
138628 D8TFU3 PAC:15402091 Selaginella moellendorffii 269  
14347 D8S6T7 PAC:15410618 Selaginella moellendorffii 309  
146897 D8RG80 PAC:15405067 Selaginella moellendorffii 409  
15419 D8RPD7 PAC:15414263 Selaginella moellendorffii 262  
172755 D8RMM5 PAC:15414268 Selaginella moellendorffii 357  
177353 D8S6X4 PAC:15403342 Selaginella moellendorffii 396  
17905 D8SN64 PAC:15401479 Selaginella moellendorffii 171  
20996 D8R337 PAC:15410820 Selaginella moellendorffii 530  
230150 D8QVZ4 PAC:15411601 Selaginella moellendorffii 445  
230900 D8R525 PAC:15417580 Selaginella moellendorffii 1340  
24258 PAC:15417035 Selaginella moellendorffii 282  
24896 D8T3A2 PAC:15421585 Selaginella moellendorffii 283  
27259 D8QUN9 PAC:15403380 Selaginella moellendorffii 180  
27438 PAC:15404847 Selaginella moellendorffii 180  
31809 D8S349 PAC:15419914 Selaginella moellendorffii 304  
37852 D8R5N6 PAC:15415313 Selaginella moellendorffii 192  
37920 D8R1B7 PAC:15416000 Selaginella moellendorffii 176  
3976 D8RFV7 PAC:15416799 Selaginella moellendorffii 154  
404078 D8QU77 PAC:15407086 Selaginella moellendorffii 597  
408264 D8R7R3 PAC:15420403 Selaginella moellendorffii 163  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            7768349
            1835513
            1956325
            1862342