Protein Domain : IPR021109

Type:  Domain Name:  Aspartic peptidase domain
Description:  Aspartic endopeptidases of vertebrate, fungal and retroviral origin have been characterised []. More recently, aspartic endopeptidases associated with the processing of bacterial type 4 prepilin []and archaean preflagellin have been described [, ].Structurally, aspartic endopeptidases are bilobal enzymes, each lobe contributing a catalytic Asp residue, with an extended active site cleft localised between the two lobes of the molecule. One lobe has probably evolved from the other through a gene duplication event in the distant past. In modern-day enzymes, although the three-dimensional structures are very similar, the amino acid sequences are more divergent, except for the catalytic site motif, which is very conserved. The presence and position of disulphide bridges are other conserved features of aspartic peptidases.All or most aspartate peptidases are endopeptidases. These enzymes have been assigned into clans (proteins which are evolutionary related), and further sub-divided into families, largely on the basis of their tertiary structure.These aspartate proteases all contain a common closed beta barrel structure, which includes pepsin, cathepsin, chymosin, beta-secretase, plasmepsin, plant acid proteases and retroviral proteases [, ]. Short Name:  Peptidase_aspartic_dom

2 Child Features

DB identifier Type Name
IPR013242 Domain Retroviral aspartyl protease
IPR019103 Domain Aspartic peptidase, DDI1-type

4 Contains

DB identifier Type Name
IPR001995 Domain Peptidase A2A, retrovirus, catalytic
IPR018061 Domain Peptidase A2A, retrovirus RVP subgroup
IPR001969 Active_site Aspartic peptidase, active site
IPR012848 Domain Aspartic peptidase, N-terminal

2 Cross Referencess

Identifier
G3DSA:2.40.70.10
SSF50630

1 Found In

DB identifier Type Name
IPR011969 Family Peptidase aspartic, CHP02281

0 GO Annotation

0 Parent Features

12878 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
413681 D8RPW0 PAC:15416125 Selaginella moellendorffii 472  
121417 D8SP07 PAC:15417546 Selaginella moellendorffii 533  
142401 D8QZM8 PAC:15412554 Selaginella moellendorffii 497  
403740 D8QSD6 PAC:15409548 Selaginella moellendorffii 336  
403844 D8QSQ5 PAC:15410371 Selaginella moellendorffii 353  
406655 D8R116 PAC:15417607 Selaginella moellendorffii 330  
413679 D8RPV7 PAC:15416103 Selaginella moellendorffii 234  
422290 D8SIJ5 PAC:15417306 Selaginella moellendorffii 469  
426643 D8SX13 PAC:15409627 Selaginella moellendorffii 249  
438819 D8QZN0 PAC:15401813 Selaginella moellendorffii 503  
444417 D8S9U5 PAC:15416530 Selaginella moellendorffii 420  
53966 D8S7S0 PAC:15418761 Selaginella moellendorffii 353  
64161 D8QSP8 PAC:15422693 Selaginella moellendorffii 357  
76765 D8QRA0 PAC:15418043 Selaginella moellendorffii 388  
78458 D8QUX3 PAC:15421449 Selaginella moellendorffii 395  
96804 D8RLT3 PAC:15410809 Selaginella moellendorffii 429  
105896 D8S0E4 PAC:15418077 Selaginella moellendorffii 373  
27319 D8QT62 PAC:15404044 Selaginella moellendorffii 163  
405210 D8QWL7 PAC:15411548 Selaginella moellendorffii 199  
408674 D8R9K8 PAC:15423369 Selaginella moellendorffii 408  
418789 D8S6E0 PAC:15409137 Selaginella moellendorffii 462  
410043 D8RDA8 PAC:15402556 Selaginella moellendorffii 134  
410693 D8RFJ6 PAC:15407212 Selaginella moellendorffii 347  
438360 D8QXE9 PAC:15420443 Selaginella moellendorffii 344  
441822 D8RMV1 PAC:15410951 Selaginella moellendorffii 496  
64135 D8R4E9 PAC:15422636 Selaginella moellendorffii 357  
64201 D8QRR7 PAC:15423277 Selaginella moellendorffii 367  
75184 D8QQ45 PAC:15410638 Selaginella moellendorffii 398  
417059 D8S184 PAC:15422991 Selaginella moellendorffii 407  
403622 D8QS04 PAC:15408693 Selaginella moellendorffii 506  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1455179
            14622420
            10625704
            16983194
            15153096
            12475196