Protein Domain : IPR020635

Type:  Domain Name:  Tyrosine-protein kinase, catalytic domain
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases []. Short Name:  Tyr_kinase_cat_dom

0 Child Features

4 Contains

DB identifier Type Name
IPR017441 Binding_site Protein kinase, ATP binding site
IPR001824 Conserved_site Tyrosine-protein kinase, receptor class III, conserved site
IPR008266 Active_site Tyrosine-protein kinase, active site
IPR002011 Conserved_site Tyrosine-protein kinase, receptor class II, conserved site

1 Cross References

Identifier
SM00219

23 Found Ins

DB identifier Type Name
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR009136 Family Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR020691 Family Ephrin type-A receptor 8
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR016251 Family Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR020775 Family Tyrosine-protein kinase, non-receptor Jak3
IPR020693 Family Tyrosine-protein kinase, non-receptor Jak2
IPR020776 Family Tyrosine-protein kinase, non-receptor Jak1
IPR020766 Family Receptor-like tyrosine-protein kinase kin-15/kin-16
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020455 Family Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020461 Family Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR016257 Family Ephrin receptor type-A /type-B
IPR012234 Family Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR015785 Family Mitogen-activated protein (MAP) kinase kinase kinase 10
IPR016231 Family Mitogen-activated protein (MAP) kinase kinase kinase, MLK1/MLK2/MLK4
IPR016248 Family Fibroblast growth factor receptor family
IPR016250 Family Tyrosine-protein kinase, Fes/Fps type
IPR016247 Family Tyrosine-protein kinase, receptor ROR
IPR016244 Family Tyrosine-protein kinase, HGF/MSP receptor
IPR016249 Family Tyrosine-protein kinase, Ret receptor
IPR016245 Family Tyrosine protein kinase, EGF/ERB/XmrK receptor

2 GO Annotations

GO Term Gene Name Organism
GO:0004713 IPR020635
GO:0006468 IPR020635

1 Parent Features

DB identifier Type Name
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain

106168 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
134331 D8T8A1 PAC:15410494 Selaginella moellendorffii 395  
139837 D8QMU8 PAC:15406526 Selaginella moellendorffii 246  
151233 D8RZA1 PAC:15415404 Selaginella moellendorffii 450  
108195 D8S4E3 PAC:15421379 Selaginella moellendorffii 325  
109282 D8S5L8 PAC:15402759 Selaginella moellendorffii 624  
100958 D8RT90 PAC:15404039 Selaginella moellendorffii 400  
102667 D8RV74 PAC:15407595 Selaginella moellendorffii 455  
103488 D8RWR1 PAC:15409147 Selaginella moellendorffii 561  
105160 D8RZA3 PAC:15412674 Selaginella moellendorffii 551  
110120 D8S6E1 PAC:15405055 Selaginella moellendorffii 292  
110333 D8S7C8 PAC:15406643 Selaginella moellendorffii 256  
110515 D8S7B9 PAC:15408061 Selaginella moellendorffii 256  
111790 D8S984 PAC:15412827 Selaginella moellendorffii 456  
11420 D8RT06 PAC:15402447 Selaginella moellendorffii 411  
117448 D8SID3 PAC:15405568 Selaginella moellendorffii 301  
118910 D8SKB3 PAC:15412328 Selaginella moellendorffii 285  
124341 D8ST71 PAC:15403194 Selaginella moellendorffii 308  
135805 D8TAW1 PAC:15417148 Selaginella moellendorffii 661  
138704 D8TFY8 PAC:15402745 Selaginella moellendorffii 348  
142471 D8QZU0 PAC:15412688 Selaginella moellendorffii 424  
145457 PAC:15421286 Selaginella moellendorffii 340  
149289 D8RRW4 PAC:15409318 Selaginella moellendorffii 360  
154240 D8SCF4 PAC:15401760 Selaginella moellendorffii 288  
159063 D8SX29 PAC:15414986 Selaginella moellendorffii 423  
169795 D8RB18 PAC:15405165 Selaginella moellendorffii 947  
171183 D8RG24 PAC:15406707 Selaginella moellendorffii 360  
171221 PAC:15407246 Selaginella moellendorffii 335  
173095 D8RP74 PAC:15411886 Selaginella moellendorffii 668  
17512 D8SLW4 PAC:15420773 Selaginella moellendorffii 180  
17623 D8T104 PAC:15421442 Selaginella moellendorffii 178  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            19275641
            16700535
            15845350