Protein Domain : IPR011009

Type:  Domain Name:  Protein kinase-like domain
Description:  Protein kinases () modify other proteins by chemically adding phosphate groups to them. This process is fundamental to most signalling and regulatory processes in the eukaryotic cell []. The protein kinases contain a catalytic core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond. The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include:the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and, as such, is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion []choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine []3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics []This entry represents the protein-kinase domain and other related domains that share a similar structure. Short Name:  Kinase-like_dom

8 Child Features

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR004147 Domain UbiB domain
IPR002575 Domain Aminoglycoside phosphotransferase
IPR000403 Domain Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR015275 Domain Actin-fragmin kinase, catalytic domain
IPR000687 Domain RIO kinase
IPR004166 Domain MHCK/EF2 kinase
IPR015897 Domain CHK kinase-like

10 Contains

DB identifier Type Name
IPR007521 Domain Choline kinase, N-terminal
IPR017441 Binding_site Protein kinase, ATP binding site
IPR001824 Conserved_site Tyrosine-protein kinase, receptor class III, conserved site
IPR008266 Active_site Tyrosine-protein kinase, active site
IPR018936 Conserved_site Phosphatidylinositol 3/4-kinase, conserved site
IPR002011 Conserved_site Tyrosine-protein kinase, receptor class II, conserved site
IPR008271 Active_site Serine/threonine-protein kinase, active site
IPR003605 Domain GS domain
IPR003527 Conserved_site Mitogen-activated protein (MAP) kinase, conserved site
IPR018935 Conserved_site RIO kinase, conserved site

1 Cross References

Identifier
SSF56112

60 Found Ins

DB identifier Type Name
IPR020636 Family Calcium/calmodulin-dependent/calcium-dependent protein kinase
IPR015433 Family Phosphatidylinositol Kinase
IPR017407 Family Serine/threonine-protein kinase Rio1
IPR017348 Family Serine/threonine-protein kinase pim-1/2/3
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR009136 Family Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR008290 Family Phosphatidylinositol 3-kinase, Vps34 type
IPR020691 Family Ephrin type-A receptor 8
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR016251 Family Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR020775 Family Tyrosine-protein kinase, non-receptor Jak3
IPR020693 Family Tyrosine-protein kinase, non-receptor Jak2
IPR020776 Family Tyrosine-protein kinase, non-receptor Jak1
IPR020766 Family Receptor-like tyrosine-protein kinase kin-15/kin-16
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020455 Family Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020461 Family Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020679 Family Serine/threonine-protein kinase Tda1
IPR020675 Family Myosin light chain kinase-related
IPR015725 Family Telokin/Myosin light chain kinase
IPR015726 Family Serine/threonine protein kinase, striated muscle-specific
IPR020676 Family Death-associated protein kinase 1
IPR016257 Family Ephrin receptor type-A /type-B
IPR020684 Family Rho-associated protein kinase 1/2
IPR020682 Family Obscurin-myosin light chain kinase
IPR017322 Family Receptor-interacting serine/threonine-protein kinase 2
IPR009220 Family Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
IPR012234 Family Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR015782 Family Dual specificity testis-specific protein kinase 1

0 GO Annotation

0 Parent Features

198201 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
109699 D8S6U8 PAC:15405864 Selaginella moellendorffii 627  
134331 D8T8A1 PAC:15410494 Selaginella moellendorffii 395  
134757 D8T936 PAC:15413620 Selaginella moellendorffii 122  
139837 D8QMU8 PAC:15406526 Selaginella moellendorffii 246  
151233 D8RZA1 PAC:15415404 Selaginella moellendorffii 450  
27379 D8QXH0 PAC:15404180 Selaginella moellendorffii 185  
108195 D8S4E3 PAC:15421379 Selaginella moellendorffii 325  
109282 D8S5L8 PAC:15402759 Selaginella moellendorffii 624  
100958 D8RT90 PAC:15404039 Selaginella moellendorffii 400  
101192 PAC:15423268 Selaginella moellendorffii 333  
101524 D8RSZ6 PAC:15403794 Selaginella moellendorffii 221  
102667 D8RV74 PAC:15407595 Selaginella moellendorffii 455  
103488 D8RWR1 PAC:15409147 Selaginella moellendorffii 561  
103506 D8RWQ7 PAC:15409702 Selaginella moellendorffii 455  
109677 D8S6U3 PAC:15405823 Selaginella moellendorffii 353  
10499 D8SYB4 PAC:15421970 Selaginella moellendorffii 675  
105160 D8RZA3 PAC:15412674 Selaginella moellendorffii 551  
105905 D8S0G7 PAC:15418654 Selaginella moellendorffii 395  
106238 D8S1F1 PAC:15416292 Selaginella moellendorffii 85  
106578 D8S1H5 PAC:15418686 Selaginella moellendorffii 73  
110120 D8S6E1 PAC:15405055 Selaginella moellendorffii 292  
110333 D8S7C8 PAC:15406643 Selaginella moellendorffii 256  
110515 D8S7B9 PAC:15408061 Selaginella moellendorffii 256  
112714 D8SA18 PAC:15415612 Selaginella moellendorffii 169  
111790 D8S984 PAC:15412827 Selaginella moellendorffii 456  
11420 D8RT06 PAC:15402447 Selaginella moellendorffii 411  
117448 D8SID3 PAC:15405568 Selaginella moellendorffii 301  
118910 D8SKB3 PAC:15412328 Selaginella moellendorffii 285  
122114 D8SQ17 PAC:15418159 Selaginella moellendorffii 67  
122408 D8SQ96 PAC:15420456 Selaginella moellendorffii 724  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12191603
            11090628
            12791258
            11467935