Protein Domain : IPR016024

Type:  Domain Name:  Armadillo-type fold
Description:  This entry represents a structural domain with an armadillo (ARM)-like fold, consisting of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis []. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. Domains and repeats with an ARM-like fold have been found in a number of proteins, including:ARM repeat domain, found in beta-catenins, importins, karyopherin and exportins.HEAT repeat domain, found in protein phosphatase 2a and initiation factor eIF4G.PHAT domain, found in the RNA-binding protein Smaug.Leucine-rich repeat variant, which contain an FeS cluster.Pumilo repeat domain, found in Pumilo protein.Regulatory subunit H of V-type ATPases.PBS lyase HEAT-like repeat.Mo25 protein.MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80.The N-terminal domain of eukaryotic translation initiation factor 3 subunit 12.The C-terminal domain of leukotriene A4 hydrolase.The helical domain of phosphoinositide 3-kinase.The N-terminal fragment of adaptin alpha-C and beta subunits.The proximal leg segment and the linker domain of the clathrin heavy chain.The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity.Furthermore, the number of repeats present in the superhelical structure can vary between orthologues, indicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats []. Short Name:  ARM-type_fold

8 Child Features

DB identifier Type Name
IPR011989 Domain Armadillo-like helical
IPR003307 Domain W2 domain
IPR016021 Domain MIF4G-like domain
IPR015211 Domain Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR001263 Domain Phosphoinositide 3-kinase, accessory (PIK) domain
IPR015327 Domain Smaug, pseudo-HEAT analogous topology
IPR016020 Domain Translation initiation factor 3, subunit 12, N-terminal, eukaryotic
IPR014768 Domain Rho GTPase-binding/formin homology 3 (GBD/FH3) domain

38 Contains

DB identifier Type Name
IPR021133 Repeat HEAT, type 2
IPR000225 Repeat Armadillo
IPR003890 Domain MIF4G-like, type 3
IPR015174 Domain MIF4G-like, type 2
IPR015172 Domain MIF4G-like, type 1
IPR000547 Repeat Clathrin, heavy chain/VPS, 7-fold repeat
IPR015348 Domain Clathrin, heavy chain, linker, core motif
IPR013713 Domain Exportin/Importin, Cse1-like
IPR016021 Domain MIF4G-like domain
IPR002015 Repeat Proteasome/cyclosome repeat
IPR000357 Repeat HEAT repeat
IPR022707 Domain Domain of unknown function DUF3535
IPR007701 Domain Interferon-related developmental regulator, N-terminal
IPR015403 Domain Domain of unknown function DUF1981, Sec7 associated
IPR012978 Domain Uncharacterised domain NUC173
IPR007205 Domain Protein HGH1 N-terminal
IPR010314 Domain E3 ubiquitin ligase, domain of unknown function DUF913
IPR013180 Domain Beta-catenin-like protein 1, N-terminal
IPR006887 Domain Domain of unknown function DUF625
IPR011430 Domain Down-regulated-in-metastasis protein
IPR013721 Domain STAG
IPR020839 Domain Stromalin conservative domain
IPR004155 Repeat PBS lyase HEAT-like repeat
IPR012977 Domain Uncharacterised domain NUC130/133, N-terminal
IPR011987 Domain ATPase, V1 complex, subunit H, C-terminal
IPR012993 Domain UME
IPR022716 Domain Domain of unknown function DUF3554
IPR012583 Domain Pre-rRNA-processing protein RIX1, N-terminal
IPR006953 Domain Vesicle tethering protein Uso1/P115-like , head domain
IPR006955 Domain Uso1/p115-like vesicle tethering protein, C-terminal

1 Cross References


16 Found Ins

DB identifier Type Name
IPR016341 Family Clathrin, heavy chain
IPR016528 Family Vacuolar protein sorting-associated protein 11
IPR012502 Family Wings apart-like, metazoan/plants
IPR013878 Family Mo25-like
IPR004083 Family Regulatory associated protein of TOR
IPR016460 Family Coatomer beta subunit (COPB1)
IPR004908 Family ATPase, V1 complex, subunit H
IPR016902 Family Vacuolar protein sorting-associated protein 41
IPR008383 Family Apoptosis inhibitory 5
IPR016643 Family 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit
IPR014825 Family DNA alkylation repair enzyme
IPR012371 Family Condensin-2 complex subunit D3
IPR003913 Family Tuberin
IPR017212 Family Clathrin, heavy chain-related
IPR016441 Family TEL2-interacting protein 1
IPR000091 Family Huntingtin

1 GO Annotation

GO Term Gene Name Organism
GO:0005488 IPR016024

0 Parent Features

48686 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
109699 D8S6U8 PAC:15405864 Selaginella moellendorffii 627  
141341 D8QVR5 PAC:15408863 Selaginella moellendorffii 4668  
44944 D8SY81 PAC:15414519 Selaginella moellendorffii 392  
442892 D8RWY0 PAC:15414089 Selaginella moellendorffii 512  
10235 D8RPB0 PAC:15420408 Selaginella moellendorffii 986  
105015 D8RZ74 PAC:15411826 Selaginella moellendorffii 532  
1121 D8RC43 PAC:15404589 Selaginella moellendorffii 492  
115849 D8SFU6 PAC:15402770 Selaginella moellendorffii 867  
116302 D8SGG7 PAC:15401838 Selaginella moellendorffii 176  
148739 D8RNY3 PAC:15410117 Selaginella moellendorffii 804  
149363 D8RS24 PAC:15410048 Selaginella moellendorffii 1082  
149750 D8RTG1 PAC:15413124 Selaginella moellendorffii 1700  
164894 D8QRW5 PAC:15413783 Selaginella moellendorffii 955  
166330 D8QX59 PAC:15415632 Selaginella moellendorffii 587  
166978 D8R0N0 PAC:15420272 Selaginella moellendorffii 708  
171350 D8RGL1 PAC:15408091 Selaginella moellendorffii 548  
175519 D8RYY9 PAC:15421246 Selaginella moellendorffii 888  
185511 D8T554 PAC:15406148 Selaginella moellendorffii 806  
230150 D8QVZ4 PAC:15411601 Selaginella moellendorffii 445  
230900 D8R525 PAC:15417580 Selaginella moellendorffii 1340  
235486 D8SY54 PAC:15406182 Selaginella moellendorffii 926  
266556 D8QMK6 PAC:15409102 Selaginella moellendorffii 527  
267278 D8REP6 PAC:15409786 Selaginella moellendorffii 439  
269184 D8SU50 PAC:15414966 Selaginella moellendorffii 871  
271123 D8RVM8 PAC:15420879 Selaginella moellendorffii 418  
33372 D8SK10 PAC:15421989 Selaginella moellendorffii 367  
40092 D8SXM9 PAC:15418286 Selaginella moellendorffii 729  
403954 D8QT39 PAC:15411178 Selaginella moellendorffii 630  
404660 D8QW06 PAC:15411803 Selaginella moellendorffii 1715  
405981 D8R0A0 PAC:15417039 Selaginella moellendorffii 935  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID