Protein Domain : IPR011990

Type:  Domain Name:  Tetratricopeptide-like helical domain
Description:  The tetratrico peptide repeat region (TPR) is a structural motif present in a wide range of proteins [, , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes []. The TPR motifconsists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs canbe dispersed in the protein sequence. Sequence alignment of the TPR domains reveals aconsensus sequence defined by a pattern of small and large amino acids. TPR motifs have beenidentified in various different organisms, ranging from bacteria to humans. Proteins containingTPRs are involved in a variety of biological processes, such as cell cycle regulation,transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis andprotein folding.The X-ray structure of a domain containing three TPRs from protein phosphatase 5 revealed thatTPR adopts a helix-turn-helix arrangement, with adjacent TPR motifs packing in a parallelfashion, resulting in a spiral of repeating anti-parallel alpha-helices []. The two helices are denotedhelix A and helix B. The packing angle between helix A and helix B is ~24 degrees within asingle TPR and generates a right-handed superhelical shape. Helix A interacts with helix B andwith helix A' of the next TPR. Two protein surfaces are generated: the inner concave surface iscontributed to mainly by residue on helices A, and the other surface presents residues from bothhelices A and B. This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis []. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains, including the tetratricopeptide repeat (TPR) (found in kinesin light chains, SNAP regulatory proteins, clathrin heavy chains and bacterial aspartyl-phosphate phosphatases), and the pentatricopeptide repeat (PPR) (RNA-processing proteins). The TPR is likely to be an ancient repeat, since it is found in eukaryotes, bacteria and archaea, whereas the PPR repeat is found predominantly in higher plants. The superhelix formed from these repeats can bind ligands at a number of different regions, and has the ability to acquire multiple functional roles []. Short Name:  TPR-like_helical_dom

0 Child Features

10 Contains

DB identifier Type Name
IPR013026 Domain Tetratricopeptide repeat-containing domain
IPR013105 Repeat Tetratricopeptide repeat 2
IPR011717 Repeat Tetratricopeptide TPR-4
IPR001440 Repeat Tetratricopeptide repeat 1
IPR006597 Repeat Sel1-like repeat
IPR003107 Repeat HAT (Half-A-TPR) repeat
IPR011716 Repeat Tetratricopeptide TPR-3
IPR019544 Domain Tetratricopeptide, SHNi-TPR domain
IPR019568 Domain Rapsyn, myristoylation/linker region, N-terminal
IPR015792 Repeat Kinesin light chain repeat

1 Cross References

Identifier
G3DSA:1.25.40.10

28 Found Ins

DB identifier Type Name
IPR013940 Family Meiosis specific protein Spo22/ZIP4/TEX11
IPR000744 Family NSF attachment protein
IPR016341 Family Clathrin, heavy chain
IPR010547 Family Plant specific mitochondrial import receptor subunit TOM20
IPR016543 Family Mitochondria fission 1 protein
IPR021183 Family N-terminal acetyltransferase A, auxiliary subunit
IPR006822 Family Coatomer, epsilon subunit
IPR017689 Family Outer membrane protein assembly factor BamD
IPR005158 Domain Bacterial transcriptional activator domain
IPR002151 Family Kinesin light chain
IPR011236 Family Serine/threonine protein phosphatase 5
IPR001237 Family 43kDa postsynaptic protein
IPR017400 Family Eukaryotic elongation factor 2 kinase
IPR009211 Family Predicted virulence protein, SciE type
IPR005254 Family Heme biosynthesis-associated TPR protein
IPR005687 Family Mitochondrial outer membrane translocase complex, subunit Tom70
IPR016931 Family Uncharacterised conserved protein UCP029658, TPR
IPR016684 Family Type III secretion system chaperone, YscY
IPR014266 Family PEP-CTERM system TPR-repeat lipoprotein, putative
IPR014562 Family Uncharacterised conserved protein UCP030959, divergent TPR repeat-containing
IPR014162 Domain Tol-Pal system, YbgF
IPR013360 Family Pilus biogenesis/stability type IV, PilW
IPR003921 Family Cellulose synthase, subunit C
IPR016379 Family Type III secretion system, low calcium response, chaperone LcrH/SycD, subgroup
IPR005415 Family Type III secretion system, low calcium response, chaperone LcrH/SycD
IPR014460 Family Signal transduction response regulator, predicted, VieB
IPR016982 Family Uncharacterised conserved protein UCP031802
IPR014596 Family Uncharacterised conserved protein UCP035836

1 GO Annotation

GO Term Gene Name Organism
GO:0005515 IPR011990

0 Parent Features

93289 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
107614 D8S3N8 PAC:15422081 Selaginella moellendorffii 273  
109709 D8S6M1 PAC:15406435 Selaginella moellendorffii 219  
110876 D8S804 PAC:15410668 Selaginella moellendorffii 237  
123482 D8SRS8 PAC:15423441 Selaginella moellendorffii 259  
123922 D8SSG2 PAC:15404802 Selaginella moellendorffii 668  
124927 D8SUB0 PAC:15407729 Selaginella moellendorffii 492  
125795 D8SVF7 PAC:15409393 Selaginella moellendorffii 156  
125978 D8SVP4 PAC:15410930 Selaginella moellendorffii 296  
126075 D8SVS4 PAC:15406839 Selaginella moellendorffii 275  
126411 D8SWD3 PAC:15409831 Selaginella moellendorffii 331  
126772 D8SWV5 PAC:15412285 Selaginella moellendorffii 380  
126864 D8SWN9 PAC:15413060 Selaginella moellendorffii 589  
126951 D8SX73 PAC:15413840 Selaginella moellendorffii 300  
127153 D8SXF5 PAC:15410600 Selaginella moellendorffii 345  
128660 D8SZR2 PAC:15417318 Selaginella moellendorffii 439  
129183 D8T0J3 PAC:15416441 Selaginella moellendorffii 214  
130516 D8T2P0 PAC:15422509 Selaginella moellendorffii 487  
130525 D8T2M7 PAC:15422545 Selaginella moellendorffii 756  
130540 D8T2P4 PAC:15422601 Selaginella moellendorffii 261  
131170 D8T3L3 PAC:15422505 Selaginella moellendorffii 849  
132132 D8T4W8 PAC:15402995 Selaginella moellendorffii 199  
132923 D8T660 PAC:15409179 Selaginella moellendorffii 238  
132950 D8T6D2 PAC:15409253 Selaginella moellendorffii 582  
133535 D8T6Z0 PAC:15409037 Selaginella moellendorffii 376  
136113 D8TBC6 PAC:15414820 Selaginella moellendorffii 630  
135839 D8TAT8 PAC:15417209 Selaginella moellendorffii 249  
135885 D8TAW0 PAC:15417325 Selaginella moellendorffii 246  
133872 D8T7M2 PAC:15411499 Selaginella moellendorffii 223  
134108 D8T851 PAC:15408811 Selaginella moellendorffii 310  
134446 D8T8G8 PAC:15411289 Selaginella moellendorffii 690  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9482716
            7667876
            1882418
            14659697
            10361086
            11551174