Protein Domain : IPR027417

Type:  Domain Name:  P-loop containing nucleoside triphosphate hydrolase
Description:  The P-loop NTPase fold is the most prevalent domain of the several distinctnucleotide-binding protein folds.The most common reaction catalysed by enzymes of the P-loop NTPase fold is the hydrolysis of the beta-gamma phosphate bond of a bound nucleoside triphosphate (NTP). The energy from NTP hydrolysis is typically utilised to induce conformational changes in other molecules, which constitutes the basis of the biological functions of most P-loop NTPases. P-loop NTPases show substantial substrate preference for either ATP or GTP []. P-loop NTPases are characterised by two conserved sequence signatures, theWalker A The Walker A motif (the P-loop proper) and Walker B motifs which bind, respectively, the beta and gamma phosphate moieties of the bound NTP, and a Mg2+ cation [].P-loop ATPase domains belong to one of the two major divisions. The kinase-GTPase (KG) division includes the kinases and GTPases, and the ASCE division, characterised by an additional strand in the core sheet, which is locatedbetween the P-loop strand and the Walker B strand. Most members of the ASCE division utilise ATP and members of this group include AAA+, ABC, PilT, HerA-FtsK, superfamily 1/2 (SF1/2) helicases, and the RecA/ATP-synthase superfamilies of ATPases, etc [, ]. Short Name:  P-loop_NTPase

31 Child Features

DB identifier Type Name
IPR003593 Domain AAA+ ATPase domain
IPR011579 Domain ATPase domain
IPR005225 Domain Small GTP-binding protein domain
IPR030393 Domain EngB-type guanine nucleotide-binding (G) domain
IPR031166 Domain EngA-type guanine nucleotide-binding (G) domain
IPR031314 Domain Deoxynucleoside kinase domain
IPR002611 Domain IstB-like ATP-binding protein
IPR001208 Domain MCM domain
IPR030378 Domain Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
IPR031167 Domain OBG-type guanine nucleotide-binding (G) domain
IPR030381 Domain Dynamin-type guanine nucleotide-binding (G) domain
IPR030386 Domain GB1/RHD3-type guanine nucleotide-binding (G) domain
IPR025723 Domain Anion-transporting ATPase-like domain
IPR030394 Domain HflX-type guanine nucleotide-binding (G) domain
IPR008145 Domain Guanylate kinase/L-type calcium channel beta subunit
IPR002586 Domain CobQ/CobB/MinD/ParA nucleotide binding domain
IPR013317 Domain Chromosomal replication initiator protein DnaA
IPR001609 Domain Myosin head, motor domain
IPR006703 Domain AIG1-type guanine nucleotide-binding (G) domain
IPR030388 Domain Era-type guanine nucleotide-binding (G) domain
IPR000863 Domain Sulfotransferase domain
IPR014774 Domain KaiC-like domain
IPR025669 Domain AAA domain
IPR010372 Domain DNA polymerase III delta, N-terminal
IPR004435 Domain Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB) domain
IPR030389 Domain FeoB-type guanine nucleotide-binding (G) domain
IPR030385 Domain IRG-type guanine nucleotide-binding (G) domain
IPR030383 Domain Very large inducible GTPASE (VLIG)-type guanine nucleotide-binding (G) domain
IPR002543 Domain FtsK domain
IPR003714 Domain PhoH-like protein

0 Contains

2 Cross Referencess


0 Found In

0 GO Annotation

0 Parent Features

214848 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
406758 D8R2U8 PAC:15418377 Selaginella moellendorffii 497  
134279 D8T898 PAC:15409784 Selaginella moellendorffii 524  
413866 D8RQG9 PAC:15417578 Selaginella moellendorffii 4796  
418928 D8S792 PAC:15410584 Selaginella moellendorffii 616  
427148 D8SYN4 PAC:15408688 Selaginella moellendorffii 444  
429837 D8T7G7 PAC:15419906 Selaginella moellendorffii 276  
412715 D8RL92 PAC:15413860 Selaginella moellendorffii 194  
427106 D8SYI9 PAC:15408572 Selaginella moellendorffii 306  
443265 D8RZZ4 PAC:15412261 Selaginella moellendorffii 303  
100977 D8RT17 PAC:15404084 Selaginella moellendorffii 617  
101338 D8RT52 PAC:15402365 Selaginella moellendorffii 1426  
102612 D8RVF8 PAC:15407465 Selaginella moellendorffii 492  
102849 D8RVC9 PAC:15409196 Selaginella moellendorffii 1017  
103446 PAC:15409028 Selaginella moellendorffii 197  
105019 D8RZ41 PAC:15411828 Selaginella moellendorffii 426  
106391 D8S1Q0 PAC:15417178 Selaginella moellendorffii 625  
10677 D8RBM0 PAC:15423455 Selaginella moellendorffii 614  
110012 D8S6U7 PAC:15404240 Selaginella moellendorffii 244  
110609 D8S7E3 PAC:15408882 Selaginella moellendorffii 206  
110652 D8S7E6 PAC:15408993 Selaginella moellendorffii 188  
113038 D8SAY7 PAC:15413237 Selaginella moellendorffii 241  
115313 D8SF78 PAC:15421173 Selaginella moellendorffii 469  
111217 D8S921 PAC:15408757 Selaginella moellendorffii 500  
111338 D8S930 PAC:15409614 Selaginella moellendorffii 614  
111419 D8S940 PAC:15410387 Selaginella moellendorffii 616  
111677 D8S915 PAC:15412014 Selaginella moellendorffii 402  
114371 D8SD53 PAC:15418481 Selaginella moellendorffii 696  
111871 D8S9P9 PAC:15413580 Selaginella moellendorffii 876  
115678 D8SFT5 PAC:15401335 Selaginella moellendorffii 1064  
118774 D8SK89 PAC:15410976 Selaginella moellendorffii 595  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID